Molecular structure of Melittin, CAS Number: 37231-28-0
Melittin (CAS 37231-28-0)
See product citations (2)
Alternate Names:
GIGAVLKVLTTGLPALISWIKRKRQQ-NH2
Application:
Melittin is an apoptosis inducer, NF-κB inhibitor, and PLA2 activator
CAS Number:
37231-28-0
Purity:
≥97%
Molecular Weight:
2846.45
Molecular Formula:
C131H229N39O31
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Melittin, a 26 amino acid long alpha-helical polypeptide is an antibacterial originally derived from Apis mellifera, has been reported to induce pores in membranes and cause apoptosis via induction of reactive oxygen species production in cells. Additionally, this compound has been found to suppress 4alpha-Phorbol 12-myristate 13-acetate (sc-202021) induced invasion of proliferative cells via inhibition of activator protein-1 and NF-kappaB. Other experiments show Melittin to be able to also suppress PMA-induced phosphorylation of ERK and JNK mitogen-activated protein kinases. This compound also activates phospholipase A2 (PLA2).
Melittin (CAS 37231-28-0) References
- Melittin as a permeability enhancer II: in vitro investigations in human mucus secreting intestinal monolayers and rat colonic mucosae. | Maher, S., et al. 2007. Pharm Res. 24: 1346-56. PMID: 17380268
- Activation of ERK1/2 in the primary injury site is required to maintain melittin-enhanced wind-up of rat spinal wide-dynamic-range neurons. | Yu, YQ., et al. 2009. Neurosci Lett. 459: 137-41. PMID: 19427362
- Melittin suppresses PMA-induced tumor cell invasion by inhibiting NF-kappaB and AP-1-dependent MMP-9 expression. | Park, JH., et al. 2010. Mol Cells. 29: 209-15. PMID: 20082219
- Postantibiotic effect of purified melittin from honeybee (Apis mellifera) venom against Escherichia coli and Staphylococcus aureus. | Han, S., et al. 2009. J Asian Nat Prod Res. 11: 796-804. PMID: 20183327
- Melittin induces apoptotic features in Candida albicans. | Park, C. and Lee, DG. 2010. Biochem Biophys Res Commun. 394: 170-2. PMID: 20188067
- Effects of melittin on endothelium-dependent relaxation and cyclic GMP levels in rat aorta. | Rapoport, RM., et al. 1989. Circ Res. 64: 463-73. PMID: 2537155
- Therapeutic effect of melittin on a rat model of chronic prostatitis induced by Complete Freund's Adjuvant. | Lin, L., et al. 2017. Biomed Pharmacother. 90: 921-927. PMID: 28441718
- Emulsion-Based Intradermal Delivery of Melittin in Rats. | Han, SM., et al. 2017. Molecules. 22: PMID: 28534835
- Influence of Supplementation of Lactoferrin, Melittin and Cecropin A to Rat Diet on Changes in Faecal Ammonia Concentrations, Short-Chain Fatty Acid Concentrations and Activities of Bacterial Enzymes. | Juśkiewicz, J., et al. 2021. Animals (Basel). 11: PMID: 33922154
- Hepatoprotective activity of melittin on isoniazid- and rifampicin-induced liver injuries in male albino rats. | Naji, KM., et al. 2021. BMC Pharmacol Toxicol. 22: 39. PMID: 34217369
- Ceftriaxone and Melittin Synergistically Promote Wound Healing in Diabetic Rats. | Alhakamy, NA., et al. 2021. Pharmaceutics. 13: PMID: 34683915
- Melittin administration ameliorates motor function, prevents apoptotic cell death and protects Purkinje neurons in the rat model of cerebellar ataxia induced by 3-Acetylpyridine. | Ghorbani, Z., et al. 2022. Toxicon. 205: 57-66. PMID: 34793821
- Melittin regulates iron homeostasis and mediates macrophage polarization in rats with lumbar spinal stenosis. | Kim, H., et al. 2022. Biomed Pharmacother. 156: 113776. PMID: 36244265
- Melittin ameliorates motor function and prevents autophagy-induced cell death and astrogliosis in rat models of cerebellar ataxia induced by 3-acetylpyridine. | Aghighi, Z., et al. 2022. Neuropeptides. 96: 102295. PMID: 36280441
- Melittin increases AMPA receptor affinity in rat brain synaptoneurosomes. | Bernard, J., et al. 1995. Brain Res. 671: 195-200. PMID: 7743208
Inhibitor of:
PKC, and Ser/Thr Protein Kinase.Activator of:
Gγ 1, group II sPLA2, group IIC sPLA2, group III sPLA2, group IVC sPLA2, group IVD sPLA2, MAS1L, PLA2, Platelet receptor Gi24, RGS8, sPLA2, and TGaseZ.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Melittin, 500 µg | sc-200868 | 500 µg | $196.00 | |||
Melittin, 1 mg | sc-200868A | 1 mg | $339.00 | |||
Melittin, 10 mg | sc-200868B | 10 mg | $787.00 |