GRAP1 Activators
GRAP1 activators are chemicals that indirectly modulate the function of GRAP1 by targeting various signaling pathways and cellular processes. These activators work by either enhancing or inhibiting the activity of enzymes, receptor pathways, or structural proteins that are indirectly associated with GRAP1 functions. For instance, compounds like Forskolin and IBMX elevate the levels of cAMP, a secondary messenger that plays a pivotal role in the regulation of numerous signaling cascades that could interface with GRAP1-mediated signal transduction. In contrast, PMA and Okadaic Acid target protein kinase C and phosphatases, respectively, leading to changes in protein phosphorylation states, which can alter GRAP1-related activities.
Additionally, the use of inhibitors such as Y-27632 and Blebbistatin, by targeting molecules that control the cytoskeleton, present a means through which GRAP1's role in the organization of cellular architecture and motility can be modulated.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Elevates intracellular cAMP by activating adenylate cyclase, which can modulate signaling pathways that GRAP1 is a part of, indirectly affecting its adaptor activity within the cell. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Non-selective inhibitor of phosphodiesterases, increases cAMP levels, potentially enhancing the signaling cascades that involve GRAP1 function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activator of Protein Kinase C (PKC) which is involved in numerous signaling pathways. PKC activation can lead to changes in cytoskeletal organization and cellular adhesion, processes in which GRAP1 may play a part. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Inhibits protein phosphatases PP1 and PP2A, leading to increased phosphorylation within cellular proteins, potentially influencing GRAP1-related signaling pathways. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
ROCK inhibitor that affects cytoskeleton dynamics and cell motility, possibly modifying GRAP1 function. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
Calmodulin antagonist, can influence calcium signaling pathways and potentially impact GRAP1 activity by affecting calcium-dependent processes. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
Inhibits Ca2+/calmodulin-dependent protein kinase II (CaMKII), potentially affecting signaling pathways that involve GRAP1. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Inhibits myosin II ATPase activity, affecting cytoskeletal dynamics and cell motility, which may have downstream effects on GRAP1-related pathways. | ||||||