GPVI Activators
Glycoprotein VI (GPVI) is a protein found on the surface of platelets and is involved in platelet aggregation. While direct chemical activators of GPVI aren't well characterized, several compounds may indirectly influence GPVI function through associated pathways or cellular processes. GPVI Activators represent a diverse class of chemicals that can influence the function of GPVI, a key protein in platelet aggregation. While direct activation of GPVI is not well documented, these compounds can indirectly influence the function of GPVI through their effects on platelet activation and aggregation.
Compounds like collagen and convulxin can bind to GPVI and induce platelet aggregation. Other chemicals such as thrombin, epinephrine, adenosine diphosphate (ADP), arachidonic acid, U46619, phorbol 12-myristate 13-acetate (PMA), ionomycin, thapsigargin, A23187, and SFLLRN can stimulate platelet activation and aggregation, potentially influencing GPVI indirectly. The effects of these chemicals on GPVI function are context-dependent and may vary based on the cellular environment and other biochemical parameters.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $235.00 | ||
Though not a direct activator of GPVI, thrombin can stimulate platelet activation and aggregation, potentially influencing GPVI indirectly. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine can enhance platelet aggregation, which may indirectly affect GPVI. | ||||||
Adenosine-5′-Diphosphate, free acid | 58-64-0 | sc-291846 sc-291846A sc-291846B sc-291846C sc-291846D sc-291846E | 100 mg 500 mg 1 g 10 g 100 g 500 g | $79.00 $184.00 $348.00 $942.00 $4688.00 $9370.00 | 1 | |
ADP can stimulate platelet activation and aggregation, potentially influencing GPVI indirectly. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic acid can stimulate platelet activation and aggregation, potentially influencing GPVI indirectly. | ||||||
U-46619 | 56985-40-1 | sc-201242 sc-201242A | 1 mg 10 mg | $245.00 $1301.00 | 40 | |
This synthetic analogue of thromboxane A2 can stimulate platelet activation and aggregation, potentially influencing GPVI. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA can activate protein kinase C, which can lead to platelet activation, potentially influencing GPVI. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin can increase intracellular calcium concentration, leading to platelet activation, potentially influencing GPVI. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin can increase intracellular calcium concentration, leading to platelet activation, potentially influencing GPVI. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
This calcium ionophore can increase intracellular calcium concentration, leading to platelet activation, potentially influencing GPVI. | ||||||