GPR63 Activators
GPR63 activators, as a chemical class, include a variety of compounds that have the capacity to modulate intracellular second messenger systems, particularly those involving cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). These molecules are pivotal in the transduction of signals from G protein-coupled receptors (GPCRs) to their intracellular targets. Agents like forskolin, isoproterenol, and various prostaglandins can directly or indirectly stimulate the production of cAMP, which is a common downstream effector of many GPCRs, and thereby can alter the activity of a broad range of receptors, potentially including GPR63.
Compounds that inhibit phosphodiesterases, such as IBMX, rolipram, zaprinast, sildenafil, cilostazol, vardenafil, and milrinone, prevent the degradation of cAMP and cGMP, thereby sustaining their signaling and promoting the activity of pathways that are modulated by these cyclic nucleotides. Given the ubiquitous nature of these second messengers in signaling pathways, it is plausible that these compounds can, in a non-selective manner, enhance GPR63 signaling.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
A beta-adrenergic agonist that increases cAMP levels, possibly influencing GPR63 activity through cAMP-mediated G protein signaling pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Non-specific inhibitor of phosphodiesterases, which increases cAMP by preventing its degradation, potentially modulating GPR63 signaling. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Selective inhibitor of phosphodiesterase 4, increasing cAMP levels and potentially enhancing GPR63 signaling through the cAMP pathway. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Directly activates adenylyl cyclase, increasing cAMP levels, which can modulate G protein-coupled receptor signaling including potentially GPR63. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
Inhibits phosphodiesterases 5, 6, and 9, increasing cAMP and cGMP levels which could potentially modulate GPR63 activity. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $31.00 $145.00 | 16 | |
Activates adenylate cyclase via its receptor, potentially increasing cAMP levels and indirectly affecting GPR63 signaling. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $109.00 $322.00 | 3 | |
Inhibits phosphodiesterase 3, increasing cAMP levels, and may influence GPR63 signaling through the cAMP signaling pathway. | ||||||
Vardenafil | 224785-90-4 | sc-362054 sc-362054A sc-362054B | 100 mg 1 g 50 g | $526.00 $735.00 $16653.00 | 7 | |
A phosphodiesterase 5 inhibitor that increases cGMP, potentially influencing cAMP and affecting GPR63 activity. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $165.00 $697.00 | 7 | |
Inhibits phosphodiesterase 3, leading to increased cAMP levels and potentially modulating GPR63 activity via cAMP-dependent pathways. | ||||||