GPR38 Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
EM574 | 110480-13-2 | sc-203039 | 1 mg | $306.00 | ||
EM574 acts as a selective modulator of GPR38, distinguished by its capacity to form hydrogen bonds with key amino acid residues within the receptor's binding pocket. This interaction induces conformational changes that enhance receptor activation and downstream signaling pathways. The compound exhibits unique reaction kinetics, allowing for rapid binding and dissociation, which may influence receptor desensitization and internalization processes. Its structural attributes suggest potential for selective receptor engagement, impacting cellular responses. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin may upregulate GPR38 by activating adenylate cyclase, resulting in elevated cAMP levels that could initiate a signaling cascade culminating in the transcription of GPR38. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can enhance the transcriptional activity of genes, potentially stimulating the GPR38 gene by binding to retinoic acid receptors that interact with GPR38 promoter regions. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate may enhance the upregulation of GPR38 by modulating histone deacetylase activity, leading to a more relaxed chromatin structure around the GPR38 gene, promoting its transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methylation, 5-Azacytidine could initiate the upregulation of GPR38 expression by unveiling promoter regions that were previously methylated and transcriptionally silent. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A may upregulate GPR38 by inhibiting histone deacetylase, thereby increasing acetylation levels of histones near the GPR38 gene, facilitating its transcriptional activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA could potentiate the upregulation of GPR38 through activation of protein kinase C, which may stimulate transcription factors that elevate GPR38 expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
β-estradiol could upregulate the expression of GPR38 by engaging estrogen receptors that interact with estrogen response elements linked to the GPR38 gene promoter. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
If the GPR38 gene promoter contains vitamin D response elements, Cholecalciferol could stimulate transcription by binding to the vitamin D receptor, which in turn binds to these elements. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride may upregulate GPR38 by inhibiting glycogen synthase kinase-3, a kinase that, when inhibited, could lead to the stabilization of transcription factors promoting GPR38 expression. | ||||||