Molecular structure of EM574, CAS Number: 110480-13-2
EM574 (CAS 110480-13-2)
Application:
EM574 is an erythromycin derivative that is a motilin receptor antagonist
CAS Number:
110480-13-2
Purity:
≥95%
Molecular Weight:
744.0
Molecular Formula:
C39H69NO12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
EM574, an erythromycin derivative, is reported to be a GPR38 (motilin receptor) agonist in the human gastric antrum in vitro. This compound was found to stimulate contractions of muscle strips in a concentration dependent manner via displacement of 125I-motilin bound to smooth muscle homogenates. Experiments have shown that EM574 contains the ability to stimulate cholinergic neurons in a non-vagal pathway. Additionally, this agent has been noted to have orexigenic activity with affinity for the growth-hormone secretagogue receptor.
EM574 (CAS 110480-13-2) References
- Effect of EM574 on postprandial pancreaticobiliary secretion, gastric motor activity, and emptying in conscious dogs. | Tanaka, T., et al. 1999. Dig Dis Sci. 44: 1100-6. PMID: 10389679
- EM574, an erythromycin derivative, improves delayed gastric emptying of semi-solid meals in conscious dogs. | Sato, F., et al. 2000. Eur J Pharmacol. 395: 165-72. PMID: 10794824
- Intestinal absorption and presystemic elimination of the prokinetic agent, EM574, in the rabbit. | Gan, G., et al. 2002. J Pharm Sci. 91: 217-28. PMID: 11782911
- EM574, a motilide, has an orexigenic activity with affinity for growth-hormone secretagogue receptor. | Asakawa, A., et al. 2003. J Gastroenterol Hepatol. 18: 881-2. PMID: 12795766
- Effect of 14-membered macrolide compounds on monocyte to macrophage differentiation. | Sunazuka, T., et al. 2003. J Antibiot (Tokyo). 56: 721-4. PMID: 14563163
- In vitro pharmacological characterization of mitemcinal (GM-611), the first acid-resistant non-peptide motilin receptor agonist, in smooth muscle of rabbit small intestine. | Takanashi, H., et al. 2007. Pharmacology. 79: 137-48. PMID: 17183187
- Effects of mitemcinal (GM-611), an acid-resistant nonpeptide motilin receptor agonist, on the gastrointestinal contractile activity in conscious dogs. | Ozaki, K., et al. 2007. Pharmacology. 79: 223-35. PMID: 17426410
- Effects of oral mitemcinal (GM-611), erythromycin, EM-574 and cisapride on gastric emptying in conscious rhesus monkeys. | Yogo, K., et al. 2008. Dig Dis Sci. 53: 912-8. PMID: 17934842
- Novel 12-membered non-antibiotic macrolides, EM900 series with anti-inflammatory and/or immunomodulatory activity; synthesis, structure-activity relationships and in vivo study. | Sugawara, A., et al. 2012. J Antibiot (Tokyo). 65: 487-90. PMID: 22760298
- EM574, an erythromycin derivative, is a potent motilin receptor agonist in human gastric antrum. | Satoh, M., et al. 1994. J Pharmacol Exp Ther. 271: 574-9. PMID: 7965757
- Vagus-dependent and vagus-independent mechanisms of action of the erythromycin derivative EM574 and motilin in dogs. | Inatomi, N., et al. 1996. Jpn J Pharmacol. 71: 29-38. PMID: 8791169
- EM574, an erythromycin derivative, is a motilin receptor agonist in the rabbit. | Sato, F., et al. 1997. Eur J Pharmacol. 322: 63-71. PMID: 9088872
- Effects of EM574 and cisapride on gastric contractile and emptying activity in normal and drug-induced gastroparesis in dogs. | Tanaka, T., et al. 1998. J Pharmacol Exp Ther. 287: 712-9. PMID: 9808701
Activator of:
GPR38.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EM574, 1 mg | sc-203039 | 1 mg | $306.00 |