GPR30 Activators
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein acts as a GPR30 ligand, engaging in selective receptor binding that initiates unique signaling cascades. Its isoflavonoid structure facilitates specific interactions with the receptor's binding site, promoting conformational changes that activate intracellular pathways. The compound's hydrophilic and hydrophobic balance enhances its interaction with lipid membranes, influencing receptor dynamics and modulating the kinetics of signal transduction in a nuanced manner. | ||||||
Quercetin Dihydrate | 6151-25-3 | sc-203225 sc-203225A | 5 g 25 g | $36.00 $61.00 | 1 | |
Quercetin Dihydrate functions as a GPR30 ligand, exhibiting a distinctive ability to modulate receptor activity through its flavonoid framework. This compound engages in specific hydrogen bonding and hydrophobic interactions with the receptor, leading to altered receptor conformation and downstream signaling. Its antioxidant properties may influence cellular redox states, further impacting receptor-mediated pathways and enhancing the complexity of signal modulation within various cellular environments. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
β-Estradiol acts as a GPR30 agonist, showcasing a unique capacity to influence receptor dynamics through its steroidal structure. It engages in specific hydrophobic interactions and forms critical van der Waals contacts with the receptor, facilitating conformational changes that activate distinct signaling cascades. This interaction can modulate intracellular calcium levels and influence gene expression, highlighting its role in diverse physiological processes and cellular responses. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A, an industrial chemical, indirectly activates GPR30 by influencing estrogen receptor pathways. It binds to estrogen receptors, altering their activity and subsequently impacting GPR30 activation. This compound operates through a non-genomic mechanism, affecting rapid signaling cascades and ultimately promoting GPR30 activity. | ||||||
Tamoxifen Citrate | 54965-24-1 | sc-203288 | 100 mg | $83.00 | 12 | |
Tamoxifen Citrate exhibits intriguing interactions with GPR30, characterized by its ability to stabilize receptor conformation through unique hydrogen bonding and hydrophobic interactions. This compound can induce allosteric modulation, altering receptor affinity for endogenous ligands. Its kinetic profile suggests a slow dissociation rate, allowing prolonged receptor engagement, which may lead to sustained signaling effects. This behavior underscores its potential to influence various cellular pathways and responses. | ||||||
ICI 182,780 | 129453-61-8 | sc-203435 sc-203435A | 1 mg 10 mg | $83.00 $187.00 | 34 | |
ICI 182,780 is a selective GPR30 modulator that engages in distinctive molecular interactions, particularly through its capacity to form specific electrostatic and van der Waals forces with the receptor. This compound exhibits unique binding kinetics, characterized by a rapid association phase followed by a gradual dissociation, which enhances its receptor occupancy. Its structural properties facilitate conformational changes in GPR30, potentially influencing downstream signaling cascades and cellular responses. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin acts as a GPR30 modulator, exhibiting unique binding characteristics that involve hydrophobic interactions and hydrogen bonding with the receptor. Its kinetic profile reveals a slow onset of action, allowing for sustained receptor engagement. This compound's structural flexibility enables it to induce specific conformational shifts in GPR30, which may alter signaling pathways and affect cellular behavior. Additionally, its antioxidant properties may influence receptor interactions indirectly. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenolic compound, indirectly activates GPR30 by modulating intracellular pathways. It enhances GPR30 activity through the AMP-activated protein kinase (AMPK) pathway. Resveratrol activates AMPK, leading to increased GPR30 expression and function. This compound's indirect activation of GPR30 highlights its role in integrating cellular energy status with GPR30 signaling, providing a unique avenue for modulating receptor activity. | ||||||
Diethylstilbestrol | 56-53-1 | sc-204720 sc-204720A sc-204720B sc-204720C sc-204720D | 1 g 5 g 25 g 50 g 100 g | $71.00 $287.00 $547.00 $1098.00 $2185.00 | 3 | |
Diethylstilbestrol (DES), a synthetic estrogen, directly activates GPR30 by binding to its receptor site. This compound triggers GPR30-mediated signaling events, including the activation of the PI3K/Akt pathway. DES's direct activation of GPR30 highlights its estrogenic properties, making it a compound with specific effects on GPR30 receptor activation and downstream signaling cascades. | ||||||
(S)-Equol | 531-95-3 | sc-205502 sc-205502A sc-205502B sc-205502C | 1 mg 5 mg 10 mg 25 mg | $34.00 $150.00 $260.00 $582.00 | 2 | |
S-equol, a metabolite of daidzein, indirectly activates GPR30 by influencing estrogen receptor pathways. It binds to estrogen receptors, altering their activity and subsequently impacting GPR30 activation. This compound operates through a non-genomic mechanism, affecting rapid signaling cascades and ultimately promoting GPR30 activity. S-equol's indirect activation of GPR30 highlights its role in modulating estrogen signaling pathways. | ||||||