Molecular structure of Tamoxifen Citrate, CAS Number: 54965-24-1
Tamoxifen Citrate (CAS 54965-24-1)
See product citations (12)
Application:
Tamoxifen Citrate is an antiestrogen with potent anti-cancer and PKC inhibitory activities
CAS Number:
54965-24-1
Purity:
>99%
Molecular Weight:
563.7
Molecular Formula:
C32H37NO8
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tamoxifen Citrate is a potent and selective inhibitor of PKC (protein kinase C). It is known that Tamoxifen Citrate functions in PKC epsilon translocation. Studies suggest that Tamoxifen Citrate functions as an estrogen receptor antagonist in breast tissue. Once bound to the estrogen receptor Tamoxifen Citrate will not allow any other ligand to bind to the receptor. In contrast, Tamoxifen Citrate is an agonist towards this receptor in tissues of the endometrium. Studies indicate Tamoxifen Citrate inhibits DNA synthesis and transcription by recruiting co-repressors, which stop estrogen from interacting with genes. When combined with PAX2, Tamoxifen Citrate can inhibit the proliferation of ERBB2. It is also a high affinity activator of the GPR30 receptor. Tamoxifen Citrate is an activator of Estrogen Receptor.
Tamoxifen Citrate (CAS 54965-24-1) References
- Activation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells. | Mandlekar, S., et al. 2000. Cancer Res. 60: 5995-6000. PMID: 11085519
- Tamoxifen citrate induced sperm shape abnormalities in the in vivo mouse. | Padmalatha Rai, S. and Vijayalaxmi, KK. 2001. Mutat Res. 492: 1-6. PMID: 11377238
- Effect of tamoxifen citrate on reproductive parameters of male dogs. | Corrada, Y., et al. 2004. Theriogenology. 61: 1327-41. PMID: 15036966
- Tamoxifen citrate loaded amphiphilic beta-cyclodextrin nanoparticles: in vitro characterization and cytotoxicity. | Memisoglu-Bilensoy, E., et al. 2005. J Control Release. 104: 489-96. PMID: 15911048
- Optimization of spatiotemporal gene inactivation in mouse heart by oral application of tamoxifen citrate. | Kiermayer, C., et al. 2007. Genesis. 45: 11-6. PMID: 17216603
- Evaluation of the reproductive effects of tamoxifen citrate in partial and full life-cycle studies using fathead minnows (Pimephales promelas). | Williams, TD., et al. 2007. Environ Toxicol Chem. 26: 695-707. PMID: 17447554
- Effects of tamoxifen citrate on postoperative intra-abdominal adhesion in a rat model. | Karaca, T., et al. 2013. Int J Surg. 11: 68-72. PMID: 23211136
- Opposite effects of tamoxifen on in vitro protein kinase C activity and endogenous protein phosphorylation in intact MCF-7 cells. | Issandou, M., et al. 1990. Cancer Res. 50: 5845-50. PMID: 2393853
- In vitro cytotoxicity and bioavailability of solid lipid nanoparticles containing tamoxifen citrate. | Hashem, FM., et al. 2014. Pharm Dev Technol. 19: 824-32. PMID: 24032414
- QbD-Driven Development and Validation of a HPLC Method for Estimation of Tamoxifen Citrate with Improved Performance. | Sandhu, PS., et al. 2016. J Chromatogr Sci. 54: 1373-84. PMID: 27226463
- Enhancing the Therapeutic Efficacy of Tamoxifen Citrate Loaded Span-Based Nano-Vesicles on Human Breast Adenocarcinoma Cells. | Kassem, MA., et al. 2018. AAPS PharmSciTech. 19: 1529-1543. PMID: 29470829
- Tamoxifen citrate loaded chitosan-gellan nanocapsules for breast cancer therapy: development, characterisation and in-vitro cell viability study. | Kathle, PK., et al. 2018. J Microencapsul. 35: 292-300. PMID: 29771175
- Development of Hot Melt Extruded Solid Dispersion of Tamoxifen Citrate and Resveratrol for Synergistic Effects on Breast Cancer Cells. | Chowdhury, N., et al. 2018. AAPS PharmSciTech. 19: 3287-3297. PMID: 30218267
- Inhibition of protein kinase C by tamoxifen. | O'Brian, CA., et al. 1985. Cancer Res. 45: 2462-5. PMID: 3157445
- Activation of nitric oxide synthase is involved in tamoxifen-induced apoptosis of human erythroleukemia K562 cells. | Maccarrone, M., et al. 1998. FEBS Lett. 434: 421-4. PMID: 9742967
Inhibitor of:
Estrogen Receptor, PKC, and Ser/Thr Protein Kinase.Activator of:
Estrogen Receptor, and GPR30.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tamoxifen Citrate, 100 mg | sc-203288 | 100 mg | $83.00 |