GPR3 Activators
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
D-erythro-Sphingosine-1-phosphate functions as a GPR3 ligand, exhibiting selective binding affinity that triggers distinct intracellular signaling pathways. Its unique structural conformation allows for specific interactions with receptor domains, influencing downstream effects on cellular processes. The compound's hydrophobic regions enhance membrane permeability, while its phosphate group contributes to ionic interactions, modulating receptor activation and signaling kinetics in a targeted manner. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing intracellular levels of cAMP. As GPR3 is a G protein-coupled receptor that modulates cAMP production, forskolin's activation of adenylyl cyclase would indirectly enhance GPR3 signaling by increasing its primary second messenger, cAMP. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a synthetic catecholamine that activates beta-adrenergic receptors, which can lead to increased cAMP production through Gs protein stimulation. This elevation in cAMP may enhance GPR3-associated signaling pathways, indirectly increasing GPR3 activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective phosphodiesterase-4 inhibitor, leading to the accumulation of cAMP in the cell. Increased intracellular cAMP levels can potentiate GPR3 signaling due to GPR3's involvement in cAMP-mediated signal transduction. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes that degrade cAMP. By preventing cAMP breakdown, IBMX can indirectly enhance GPR3 activity by maintaining elevated cAMP levels, which play a crucial role in GPR3's signaling pathway. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $30.00 $142.00 | 16 | |
PGE1 activates G protein-coupled E-prostanoid receptors which can lead to increased cAMP production. This rise in cAMP may indirectly enhance GPR3 signaling, given GPR3s role in cAMP-mediated pathways. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $92.00 $138.00 | ||
Salbutamol is a beta-2 adrenergic agonist that elevates cAMP levels through the activation of Gs protein-coupled receptors. The resultant increase in cAMP can enhance GPR3 activity since GPR3 is implicated in cAMP-dependent signaling. | ||||||
Anagrelide | 68475-42-3 | sc-491875 | 25 mg | $147.00 | ||
Anagrelide inhibits phosphodiesterase 3, resulting in an increase in cAMP levels within the cell. This increase in cAMP can indirectly enhance the signaling of GPR3, a receptor that operates through cAMP-dependent pathways. | ||||||
BAY 60-6583 | 910487-58-0 | sc-503262 | 10 mg | $210.00 | ||
BAY 60-6583 is an adenosine A2B receptor agonist that leads to increased intracellular cAMP. Through this mechanism, it can indirectly enhance GPR3 activity by augmenting the cAMP signaling pathway, which is central to GPR3 function. | ||||||
Zardaverine | 101975-10-4 | sc-201208 sc-201208A | 5 mg 25 mg | $88.00 $379.00 | 1 | |
Zardaverine is a dual-selective inhibitor of phosphodiesterase 3 and 4, leading to increased levels of cAMP. This elevation can indirectly potentiate GPR3 signaling due to the receptor's reliance on cAMP for its activity. | ||||||