GPR179 Inhibitors
GPR179 inhibitors like Pertussis Toxin and GDP-beta-S, interact directly with the G-proteins that are essential for transmitting the signals from GPCRs like GPR179 to their intracellular targets. Pertussis Toxin irreversibly inactivates Gi/o-type G-proteins, thereby impeding the receptor's intracellular communication, while GDP-beta-S acts as a competitive antagonist to GTP, preventing the activation of G-proteins.
Others, such as Cholera Toxin, Forskolin, and NF449, exert their effects on the secondary messenger systems that G-proteins regulate. Cholera Toxin and Forskolin influence the cAMP pathway: the former by causing a persistent activation of Gs proteins, and the latter by directly stimulating the production of cAMP, which can have a wide range of effects on cellular processes including those that may counteract GPR179-signaling. NF449 selectively inhibits the Gs alpha subunit, which may disrupt the GPR179-related signaling by undermining Gs protein's function. Further, the list includes compounds like Suramin, YM-254890, U73122, Go 6983, and M119K, each of which targets distinct aspects of G-protein signaling. Suramin acts as a general antagonist to purinergic receptors, which could lead to alterations in GPR179-related signal transduction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
Inactivates Gi/o proteins, which are often coupled to GPCRs similar to GPR179, leading to the inhibition of related signaling. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Directly activates adenylate cyclase, increasing cAMP levels and potentially counteracting GPR179-mediated signaling pathways. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $199.00 $460.00 $1479.00 | 1 | |
Inhibits Gs alpha subunit, potentially altering downstream effects of GPR179 activation. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Non-selective antagonist of G protein-coupled purinergic receptors, which may indirectly influence GPR179 signaling pathways. | ||||||
YM 254890 | 568580-02-9 | sc-507356 | 1 mg | $500.00 | ||
Specific inhibitor of Gq/11 proteins, can disrupt signaling pathways that may indirectly associate with GPR179 function. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Protein kinase C inhibitor, which may affect downstream signaling events that GPR179 participates in. | ||||||