GPR176 Activators
GPR176 Activators can be divided into several categories. The first group includes Isoproterenol, Dopamine, Glucagon, Histamine, and Noradrenaline. These neurotransmitters and hormones are known to stimulate G-protein coupled receptors (GPCRs) and increase the production of cAMP. GPR176, being a GPCR itself, is directly involved in cAMP-dependent signaling pathways. Therefore, these compounds can enhance GPR176's function by increasing intracellular cAMP levels and consequently activating the cAMP-dependent pathway in which GPR176 participates.
The second group of GPR176 activators includes Acetylcholine, L-Arginine, Sildenafil, Forskolin, Epinephrine, Adenosine, and 8-Bromo-cAMP. Acetylcholine, through its activation of muscarinic receptors, leads to the production of IP3 and DAG, which are involved in GPCR signaling pathways that GPR176 is directly involved in. L-Arginine and Sildenafil influence cGMP levels, another pathway in which GPR176 is known to be involved. L-Arginine is a substrate for nitric oxide synthases (NOS), which produce nitric oxide (NO). NO activates guanylate cyclase, leading to increased levels of cGMP, a second messenger that GPR176 can utilize. Sildenafil, by inhibiting the phosphodiesterase type 5 (PDE5), prevents cGMP degradation, leading to increased cGMP levels, thus enhancing GPR176's function. Forskolin, a plant-based compound, directly activates adenylyl cyclase, thereby increasing intracellular cAMP levels. This increase in cAMP can enhance GPR176 function via the cAMP-dependent signaling pathway. Similarly, Epinephrine and Adenosine, by stimulating GPCRs and increasing cAMP production, contribute to GPR176 activation. Lastly, 8-Bromo-cAMP, a cell-permeable cAMP analog, also increases intracellular cAMP levels and can enhance GPR176's function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist that can stimulate the production of cAMP. The increased cAMP levels can enhance GPR176 activity through the cAMP-dependent signaling pathway, a pathway in which GPR176 is directly involved. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine is a neurotransmitter that activates dopamine receptors, which are GPCRs. Dopamine can enhance GPR176 function by stimulating G-protein mediated signaling pathways that GPR176 is directly involved in. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine activates histamine receptors, which are GPCRs. Histamine can enhance GPR176 function by activating G-protein mediated signaling pathways that GPR176 is directly involved in. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $320.00 $475.00 | 3 | |
Noradrenaline is a neurotransmitter that can stimulate GPCRs, leading to an increase in intracellular cAMP levels. This increase in cAMP can enhance GPR176 function, as GPR176 is involved in cAMP-related signaling pathways. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $30.00 $60.00 $215.00 $345.00 | 2 | |
L-Arginine is a substrate for NOS, which produces NO. NO can activate guanylate cyclase, leading to increased cGMP levels. The elevated cGMP levels can enhance GPR176 function because GPR176 is involved in cGMP-dependent signaling pathways. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a compound from the plant Coleus forskohlii that directly activates adenylyl cyclase, leading to an increase in intracellular cAMP levels. As GPR176 is a GPCR, increased cAMP levels can enhance its functional activity through the cAMP-dependent signaling pathway. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine is an adrenergic receptor agonist that can stimulate the production of cAMP. Elevations in cAMP levels can lead to the functional activation of GPCRs like GPR176 through the cAMP-dependent signaling pathway. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine can stimulate GPCRs and cause an increase in intracellular cAMP levels. The increased cAMP levels can enhance GPR176's function, as GPR176 is directly involved in cAMP-dependent signaling pathways. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that can increase intracellular cAMP levels. The elevated cAMP levels can enhance GPR176's function, as GPR176 is directly involved in cAMP-dependent signaling pathways. | ||||||