GPR160 Activators
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GPR160 activators are chemical agents specifically designed to engage and activate the G protein-coupled receptor 160 (GPR160), a member of the extensive GPCR family. As a receptor class, GPCRs play a pivotal role in mediating cellular responses to a diverse range of signals, including hormones, neurotransmitters, and sensory stimuli. Activation of these receptors triggers a cascade of biochemical events within the cell, typically involving the activation of G proteins, which then modulate various downstream signaling pathways. GPR160 is a receptor encoded by the GPR160 gene, and its activation by endogenous or exogenous compounds can influence the receptor's role in the cellular signaling network.
GPR160 activators are compounds that have been tailored to bind to and activate this receptor, mimicking or enhancing the action of its natural ligand. These activators are characterized by their ability to bind to the receptor with high affinity, effectively initiating the receptor's conformational change required for G protein engagement. The specificity of GPR160 activators is critical, as it ensures that the intended receptor is selectively targeted, thereby minimizing non-specific interactions that could lead to undesired modulation of other GPCRs. The molecular design of these activators often incorporates knowledge of the receptor's structure and the ligand-receptor interactions that are key for receptor activation. The development of GPR160 activators frequently employs computational methods, such as molecular docking and virtual screening, to predict how well a compound will interact with the receptor.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
An activator of adenylate cyclase which increases cAMP levels in cells, potentially modulating the activity of GPR160 by affecting the intracellular signaling environment. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
A non-selective beta-adrenergic receptor agonist which can increase intracellular cAMP, suggesting potential modulation of GPCR activity, including GPR160, through cAMP-dependent pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
A non-selective inhibitor of phosphodiesterases, which prevents cAMP breakdown, possibly influencing GPR160 signaling by maintaining elevated levels of this secondary messenger. | ||||||
Pilocarpine | 92-13-7 | sc-479256 | 100 mg | $255.00 | 1 | |
A muscarinic acetylcholine receptor agonist that can influence GPCR function by modulating the cholinergic system and altering receptor conformation states and intracellular signaling cascades. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
A lipid signaling molecule that can activate GPCR signaling pathways by serving as a ligand for S1P receptors, potentially impacting GPR160 signaling through cross-talk between GPCR pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
An ionophore that raises intracellular calcium levels, potentially affecting GPCR signaling, including GPR160, by altering calcium-dependent signaling pathways. | ||||||
Carbachol | 51-83-2 | sc-202092 sc-202092A sc-202092C sc-202092D sc-202092B sc-202092E | 1 g 10 g 25 g 50 g 100 g 250 g | $122.00 $281.00 $388.00 $683.00 $1428.00 $3060.00 | 12 | |
A cholinergic agonist that could affect GPR160 activity indirectly through muscarinic receptor pathways and the downstream signaling cascades. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
An inhibitor of the sarcoplasmic/endoplasmic reticulum Ca²⁺ ATPase (SERCA), leading to increased cytosolic calcium concentrations, which may influence GPCR function, including GPR160, by modulating intracellular signaling pathways. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
A lipid compound that activates GPCR signaling through its own receptors and could potentially influence GPR160 signaling indirectly by affecting the prostaglandin signaling environment within cells. | ||||||