GPR101 Activators
GPR101 is an orphan G protein-coupled receptor (GPCR), meaning its endogenous ligand and physiological role are not well-defined. This receptor is predominantly expressed in the pituitary gland and the hypothalamus, regions of the brain that are critical for hormonal regulation and homeostasis. GPR101 has garnered significant interest due to its genetic association with X-linked acrogigantism (X-LAG), a condition characterized by excessive growth due to the overproduction of growth hormone.
The GPR101 gene is located on the X chromosome, and duplications in this gene are strongly linked to the development of X-LAG, suggesting that GPR101 overexpression leads to abnormal growth hormone secretion. This has led to the hypothesis that GPR101 may be involved in the signaling pathways that regulate pituitary function and growth hormone release.Despite its association with pathological growth, the normal physiological function of GPR101 remains elusive. It is speculated to be involved in neuroendocrine signaling given its expression profile. The receptor's activity and regulation could be influenced by various factors including hormones, intracellular messengers, and pharmacological agents, which may modulate its expression or activity.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can modulate GPCR expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C, which can influence GPCR gene transcription. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid regulates gene expression and may affect GPCR expression during differentiation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that can demethylate DNA and potentially upregulate gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
An HDAC inhibitor that can change chromatin structure and increase gene expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Another HDAC inhibitor that can lead to hyperacetylation of histones and affect gene expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium can modulate GSK-3 activity, influencing Wnt signaling and possibly GPCR expression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid is an HDAC inhibitor that can alter gene expression, potentially affecting GPR101. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
As a steroid hormone, estradiol can regulate gene expression through estrogen receptor-mediated signaling. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
A glucocorticoid that can modulate gene expression, including that of GPCRs. | ||||||