GPC3 Activators
GPC3, a heparan sulfate proteoglycan, plays a crucial role in modulating various signaling pathways, particularly those involved in cellular growth and development. The interaction of GPC3 with specific chemical activators elucidates its functional dynamics within these pathways. Heparin, for instance, binds directly to GPC3, potentiating its role in the Wnt signaling pathway, which is pivotal in regulating cell proliferation and growth. Similarly, Suramin's interaction with GPC3 influences the Wnt/β-catenin pathway, indirectly augmenting GPC3's regulatory role in these processes. Cholesterol and Omega-3 Fatty Acids, integral to membrane composition, enhance GPC3's signaling capacity, especially in lipid raft-associated pathways like Hedgehog signaling. Pioglitazone and Vitamin D3, by modulating lipid metabolism and growth factor pathways, respectively, indirectly increase GPC3's signaling efficiency. This enhancement is crucial for GPC3's involvement in growth regulation, demonstrating how alterations in membrane composition and growth factor interactions can impact GPC3 activity.
Further, compounds like Retinoic Acid, Curcumin, Epigallocatechin Gallate, and Sulforaphane, primarily influencing the Wnt/β-catenin pathway, indirectly enhance GPC3 function. These compounds modulate the pathway, facilitating an environment where GPC3's regulatory role is amplified, especially in cellular processes like proliferation and differentiation. Folic Acid's contribution to DNA synthesis and repair processes may also augment the functional activity of GPC3, by upregulating cellular processes in which it participates. Additionally, Lithium Chloride's inhibition of GSK-3β in the Wnt pathway indirectly boosts GPC3's role in this signaling cascade. Collectively, these GPC3 activators, through their targeted biochemical and cellular pathway influences, enhance the functional activity of GPC3, underlining its significance in growth regulation and developmental processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Heparin | 9005-49-6 | sc-507344 | 25 mg | $119.00 | 1 | |
Heparin, a highly sulfated glycosaminoglycan, binds to GPC3, enhancing its ability to modulate Wnt signaling. This interaction potentially increases the functional activity of GPC3 in growth regulation. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
Suramin, a polysulfonated naphthylurea, interacts with GPC3, affecting the Wnt/β-catenin pathway. By modulating this pathway, Suramin indirectly enhances GPC3’s role in cell proliferation and growth control. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $27.00 $2809.00 $129.00 $210.00 $583.00 $88.00 | 11 | |
Cholesterol is crucial for the functional integrity of lipid rafts. Its presence in the membrane can influence the localization and activity of GPC3, thereby affecting GPC3-mediated signaling pathways like Hedgehog. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone, a PPAR-γ agonist, can modulate lipid metabolism and may affect the membrane composition. This alteration could enhance the signaling capacity of GPC3, particularly in pathways involving cell growth. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid can regulate the expression of various growth factors and receptors. Its presence might upregulate the functional components that interact with GPC3, enhancing its signaling efficiency in growth regulation. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 modulates several growth factors and their pathways. It could enhance GPC3 signaling by upregulating factors in pathways where GPC3 is a co-receptor, like Hedgehog signaling. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can modulate the Wnt/β-catenin pathway, which is a significant pathway for GPC3. By altering this pathway, Curcumin potentially enhances the functional activity of GPC3 in cellular processes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This compound, a major catechin in green tea, can influence Wnt signaling. This modulation may enhance GPC3’s role in the pathway, particularly in processes related to growth and proliferation. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Folic Acid is essential for DNA synthesis and repair. It may enhance GPC3 activity by upregulating cellular processes where GPC3 is involved, particularly in cell growth and proliferation pathways. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $94.00 $210.00 $1779.00 $8021.00 $16657.00 | 11 | |
These fatty acids can alter membrane fluidity and lipid raft composition, potentially enhancing the signaling efficiency of membrane-bound proteins like GPC3 in pathways such as Hedgehog signaling. | ||||||