GOLGA6L1 Inhibitors
GOLGA6L1 inhibitors are chemical compounds that specifically target and modulate the activity of the GOLGA6L1 protein, a member of the Golgin family. The Golgins are a group of coiled-coil proteins primarily associated with the Golgi apparatus, an organelle responsible for processing and trafficking proteins and lipids within the cell. GOLGA6L1, like other Golgins, plays a role in maintaining the structural integrity of the Golgi and is involved in vesicle tethering and transport between the Golgi and other cellular compartments. Inhibition of GOLGA6L1 disrupts these processes, leading to alterations in Golgi morphology and function, which can affect cellular trafficking pathways. Such disruptions may cause a cascade of intracellular changes, influencing protein glycosylation, secretion, and the overall organization of the endomembrane system.
These inhibitors are typically designed with high specificity to interfere with the normal interactions of GOLGA6L1, potentially targeting its binding sites or altering its conformational state. As a result, these compounds provide a valuable tool for studying Golgi-related processes at the molecular level. By selectively inhibiting GOLGA6L1, researchers can gain insights into the broader regulatory mechanisms governing intracellular trafficking, Golgi structure, and protein sorting. Additionally, GOLGA6L1 inhibitors can help elucidate the protein's role in cellular homeostasis and the response to environmental stressors, such as oxidative damage or nutrient deprivation, contributing to a deeper understanding of Golgi dynamics and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol inhibits the motor protein Eg5, which is essential for mitotic spindle formation. As Golgin subfamily A member 6-like protein 1 is involved in Golgi apparatus structure and function, inhibiting spindle formation disrupts the Golgi apparatus, leading to a functional inhibition of Golgin subfamily A member 6-like protein 1 due to its reliance on an intact Golgi structure for proper functioning. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts Golgi structure by inhibiting ADP-ribosylation factor, a small GTPase involved in vesicle trafficking. As Golgin subfamily A member 6-like protein 1 is associated with the Golgi apparatus, this disruption leads to direct functional inhibition of Golgin subfamily A member 6-like protein 1 by compromising its structural integrity and localization. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore inhibits dynamin, a GTPase responsible for endocytosis and vesicle trafficking. By inhibiting dynamin, Golgin subfamily A member 6-like protein 1 is functionally inhibited as its role in vesicle tethering and trafficking at the Golgi is compromised due to the blockade of vesicle scission and release. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization, which is vital for Golgi apparatus positioning and function. The functional inhibition of Golgin subfamily A member 6-like protein 1 occurs as a result of impaired microtubule-dependent Golgi organization, which is essential for its activity. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $187.00 $670.00 | 11 | |
Golgicide A is a specific inhibitor of Golgi BFA resistance factor 1 (GBF1), a GEF for ARF1 GTPase. Inhibition of GBF1 disrupts ARF1-mediated recruitment of coatomer proteins, leading to functional inhibition of Golgin subfamily A member 6-like protein 1 by interfering with its Golgi localization and membrane association. | ||||||
Latrunculin B | 76343-94-7 | sc-203318 | 1 mg | $229.00 | 29 | |
Latrunculin B binds to actin monomers and prevents their polymerization. As actin dynamics are crucial for the maintenance of Golgi structure, the disruption of actin filaments leads to a functional inhibition of Golgin subfamily A member 6-like protein 1 by altering Golgi architecture and its associated functions. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, a process occurring in the Golgi. By inhibiting this process, Golgin subfamily A member 6-like protein 1 is functionally inhibited due to the reliance on proper glycosylation for its stability and function within the Golgi apparatus. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide stabilizes actin filaments and prevents their disassembly. This alteration of actin dynamics can lead to a functional inhibition of Golgin subfamily A member 6-like protein 1 by disrupting the actin-dependent maintenance of Golgi structure and function. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly. As Golgin subfamily A member 6-like protein 1 requires dynamic microtubules for its proper function within the Golgi, the stabilization of microtubules can lead to its functional inhibition by altering normal microtubule-dependent processes. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin and inhibits its polymerization into microtubules. The resulting disruption in microtubule dynamics functionally inhibits Golgin subfamily A member 6-like protein 1 by compromising microtubule-dependent Golgi organization and trafficking. | ||||||