GOLGA6A-D Activators
The chemical class designated as GOLGA6A-D activators encompasses a diverse range of compounds known to influence the cellular pathways and processes that are crucial for the functioning of the GOLGA6A-D proteins, which are part of the golgin subfamily of proteins associated with the Golgi apparatus. These activators are not recognized by their direct binding or modulation of GOLGA6A-D proteins but by their role in altering the cellular environment in a way that can lead to the activation of these proteins. The interaction between these chemicals and cellular processes includes modulation of actin and microtubule dynamics, vesicular trafficking, and signaling pathways that are intimately connected to the structural integrity and function of the Golgi apparatus. Activation of these proteins can result from changes in the cytoskeleton, which is a fundamental component for maintaining Golgi structure, as well as from alterations in vesicle formation, transport, and fusion processes that are necessary for proper Golgi function.
The chemicals classified as GOLGA6A-D activators can affect the proteins indirectly by targeting upstream regulators or components of the cellular machinery that GOLGA6A-D interacts with. By influencing the Golgi-associated activities, these compounds can alter the equilibrium and dynamics of Golgi assembly, which can have a downstream effect on the function of GOLGA6A-D proteins. For instance, compounds that stabilize or disrupt the cytoskeletal filaments can modify the positioning and morphology of the Golgi, thereby modulating the function of the GOLGA6A-D family. Similarly, molecules that interfere with vesicle trafficking can change the cargo delivery and processing, which in turn can adjust the activity state of GOLGA6A-D proteins. These activators play a significant role in the complex network of cellular mechanisms that govern the organization and maintenance of the Golgi apparatus and are valuable tools for elucidating the functional dynamics of GOLGA6A-D proteins.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which could activate protein kinase A activity and influence GOLGA6-related trafficking processes. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts Golgi structure by inhibiting ADP-ribosylation factors, which could activate GOLGA6 protein function due to alterations in Golgi dynamics. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is an ionophore that disrupts Golgi function and could activate GOLGA6 by affecting vesicle formation and transport. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization, which could activate GOLGA6 protein interaction with the cytoskeleton and influence Golgi apparatus positioning and function. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D inhibits actin polymerization, which could activate GOLGA6 by disrupting actin-dependent processes in Golgi maintenance. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules, which could activate GOLGA6 protein interactions with the Golgi and vesicle trafficking. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $48.00 $122.00 $432.00 $812.00 | 4 | |
Wiskostatin inhibits the N-WASP, which controls actin polymerization; this could activate GOLGA6's role in maintaining Golgi structure. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $153.00 $520.00 | 4 | |
ML141 is a Cdc42 inhibitor, which could activate GOLGA6 by influencing the actin cytoskeleton organization and vesicle trafficking. | ||||||
Hypoxia inducible factor-1α inhibitor | 934593-90-5 | sc-205346 sc-205346A sc-205346B sc-205346C | 1 mg 5 mg 10 mg 25 mg | $32.00 $112.00 $190.00 $403.00 | 40 | |
Golgicide A targets the Golgi brefeldin A resistant guanine nucleotide exchange factor 1 (GBF1), which could activate GOLGA6 by altering vesicle trafficking and Golgi function. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore inhibits dynamin, affecting vesicle scission, which could activate GOLGA6's role in vesicle trafficking. | ||||||