Gm590 Activators
Fam240a activators comprise a diverse group of chemical compounds that are unified by their ability to modulate the activity of the protein family with sequence similarity 240 member A, commonly known as Fam240a. These activators interact with a variety of cellular signaling pathways, influencing the activity of Fam240a through direct or indirect means. The mechanisms of action for these compounds are as varied as their structures, ranging from the alteration of intracellular second messenger concentrations to the modulation of gene expression. For instance, some activators work by increasing the levels of cyclic AMP (cAMP) within the cell, which can affect a range of proteins including protein kinases that may phosphorylate Fam240a or its associated proteins, thus regulating its activity. Other compounds in this class function by altering the balance of intracellular ions such as calcium, which is a critical cofactor for many enzymes and has a significant role in signaling cascades that could impinge upon the function of Fam240a.
The biochemical influence of Fam240a activators extends to the epigenetic level as well, where compounds such as histone deacetylase inhibitors lead to modifications in chromatin structure and, consequently, the expression of genes that are relevant to the function of Fam240a. By creating a more open chromatin conformation, these activators facilitate the transcription of specific genes, potentially leading to an increase in the synthesis of proteins that interact with or regulate Fam240a, enhancing its activity within the cell. Additionally, some members of this chemical class mimic endogenous ligands, binding to receptors and initiating signaling cascades that culminate in the activation or stabilization of proteins that work in concert with Fam240a.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diacylglycerol (DAG) analog that activates protein kinase C (PKC). PKC activation can lead to the phosphorylation of proteins within signaling pathways that Fam240a is part of, resulting in an increased functional activity of Fam240a through its association with these phosphorylated proteins. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase 3 (GSK-3). Inhibition of GSK-3 can lead to the stabilization and increased activity of β-catenin, which may interact with Fam240a or its associated proteins, thus enhancing Fam240a function in Wnt signaling pathways. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate acts as a histone deacetylase inhibitor, leading to hyperacetylation of histones and a more open chromatin structure. This alteration can increase the accessibility of transcription factors to DNA, potentially enhancing the transcription of genes that interact with or regulate Fam240a. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinase, which may phosphorylate proteins that either interact with Fam240a or are part of pathways that Fam240a is involved in, enhancing its functional activity. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin engages its receptor to initiate a signaling cascade that activates PI3K/AKT pathway. The subsequent phosphorylation events could enhance the activity of Fam240a by modulating proteins within this pathway that Fam240a either interacts with or is regulated by. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
As a reactive oxygen species, H2O2 can influence redox-sensitive signaling pathways. This can lead to the activation of redox-sensitive kinases or transcription factors that regulate the function of Fam240a or its associated proteins, thereby enhancing the activity of Fam240a. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that elevates intracellular calcium levels, which can activate calcium-dependent signaling pathways. This activation could enhance the activity of Fam240a through its role in these calcium-mediated signaling events. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic catecholamine that activates β-adrenergic receptors, which in turn increases cAMP levels and activates PKA. PKA can phosphorylate proteins within signaling pathways that Fam240a is involved in, enhancing its activity by modulating these proteins. | ||||||