Gm281 Inhibitors
The class of chemicals known as Cdhr18 inhibitors is a group of compounds that can indirectly interfere with the function of cadherin-related family member 18 through various intracellular pathways and processes. These inhibitors do not directly target CDHR18 but can affect its function by altering the cellular environment or signaling pathways that cadherins depend on. For example, chelating agents such as EDTA and EGTA can disrupt the critical calcium-dependent conformation of cadherins necessary for their adhesive functions. This disruption can lead to altered cadherin-mediated cell-cell interactions, which are essential for maintaining tissue architecture and cellular communication.
On the other hand, compounds that affect the actin cytoskeleton, such as Cytochalasin D and Latrunculin A, can impact the structural support that cadherins require for their cell surface localization and stability. Inhibitors of signaling pathways that intersect with cadherin function, such as GW5074 and XAV-939, can also modulate the expression levels or the adhesive activity of cadherins. In addition, chemicals like Y-27632 and ML-7, which target proteins involved in cytoskeletal dynamics, can indirectly influence the mechanical forces that are transmitted through cadherin junctions.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $20.00 $62.00 $116.00 $246.00 $799.00 | 23 | |
Similar to EDTA, EGTA preferentially binds calcium ions and can disrupt calcium-dependent cadherin functions. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Binds to actin filaments and prevents their polymerization, potentially disrupting the cytoskeletal interactions necessary for cadherin function. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Disrupts microfilament organization by binding to actin monomers, which can indirectly affect cadherin-mediated cell adhesion. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $71.00 $260.00 $485.00 $949.00 | ||
Inhibits myosin II activity and can affect the tension of the actomyosin network, potentially influencing cadherin dynamics. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
Inhibits myosin light chain kinase, which can alter cytoskeletal dynamics and consequently affect cadherin function. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A ROCK inhibitor that can alter cytoskeletal organization and tension, indirectly impacting cadherin interactions. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $215.00 $622.00 | 5 | |
Inhibits Ras farnesyltransferase, potentially altering cell adhesion and signaling pathways related to cadherins. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
A c-Raf kinase inhibitor that can affect downstream signaling pathways influencing cadherin-mediated adhesion. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
Inhibits the Wnt/β-catenin signaling pathway, which is implicated in the regulation of cadherin expression and function. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
A γ-secretase inhibitor that can prevent the cleavage of certain proteins involved in cell adhesion, potentially affecting cadherins. | ||||||