Gm221 Activators
Coiled-coil domain containing 170 (CCDC170) activators include chemicals that act upon signaling pathways or cellular processes that could indirectly enhance the functional activity of CCDC170. Forskolin, by activating adenylate cyclase, increases the levels of cAMP, thereby activating PKA, which can lead to phosphorylation of substrates and influence signaling pathways that CCDC170 may be a part of. If CCDC170 is associated with the PKA signaling cascade, then forskolin would enhance its activity by promoting the phosphorylation of downstream targets or altering the cellular environment in a manner that sensitizes CCDC170 to activation. Similarly, Phorbol 12-myristate 13-acetate (PMA), through activation of PKC, could enhance the functional activity of CCDC170 if it is regulated by PKC-dependent phosphorylation events. Ionomycin, by increasing intracellular calcium levels, can activate calcium-dependent proteins and pathways, potentially influencing the activity of CCDC170 if it is responsive to calcium signaling. Lithium chloride, by inhibiting GSK-3, could enhance CCDC170 activity if it is negatively regulated by GSK-3 mediated phosphorylation.
The activity of CCDC170 could also be influenced by the cellular redox state, as indicated by the inclusion of hydrogen peroxide, which might enhance CCDC170 activity if it is sensitive to oxidative signaling. Sodium butyrate, through histone deacetylase inhibition, could alter gene expression patterns to create a cellular context that enhances the activity of CCDC170, assuming it is responsive to changes in chromatin structure. Retinoic acid could act in a similar gene-regulatory fashion, influencing the activity of CCDC170 through alterations in gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which phosphorylates a wide range of cellular proteins. If CCDC170 is a PKC substrate or is regulated by PKC-dependent signaling, its functional activity could be enhanced. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Calcium signaling is vital for many cellular processes, and if CCDC170 is calcium-sensitive or involved in calcium-dependent pathways, its activity could be enhanced. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3 (GSK-3). If CCDC170's activity is negatively regulated by GSK-3, inhibition by lithium could enhance CCDC170's functional activity. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
dbcAMP is a cAMP analog that activates PKA. Like forskolin, if CCDC170's activity is modulated by PKA-dependent phosphorylation, dbcAMP could enhance its activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases intracellular cAMP levels. If CCDC170 is modulated by the beta-adrenergic signaling pathway, isoproterenol could enhance its activity via PKA activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid acts on nuclear receptors and influences gene expression. If CCDC170's functional activity is linked to retinoic acid-sensitive genes or pathways, its activity could be enhanced through this mechanism. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
Nicotinamide riboside is a precursor of NAD+, which is required for the activity of sirtuins and PARPs, and may affect ADP-ribosylation processes. If CCDC170 is modulated by these processes, its activity could be enhanced. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide is a reactive oxygen species that can act as a signaling molecule. If CCDC170 activity is modulated by redox signaling pathways, hydrogen peroxide could enhance its activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that alters chromatin structure and gene expression. If CCDC170 is modulated by the acetylation state of histones or other proteins, its activity could be enhanced by sodium butyrate. | ||||||