Glut4 Activators
Glut4 activators belong to a chemical class of compounds that influence the activity of the Glucose transporter 4 (Glut4) protein, a critical player in glucose homeostasis and cellular glucose uptake. Glut4 is primarily found in insulin-sensitive tissues, such as skeletal muscle and adipose tissue, and plays a central role in regulating glucose transport from the bloodstream into these cells. The process of Glut4 activation is essential for maintaining glucose balance and energy metabolism in the body. Glut4 activators, as a category of compounds, are characterized by their capacity to enhance the translocation of Glut4 from intracellular storage vesicles to the plasma membrane, where it can facilitate the uptake of glucose into cells.
The regulation of Glut4 activation is a tightly orchestrated process involving various signaling pathways and molecular events. Glut4 activators can operate through multiple mechanisms, some of which involve the modulation of downstream signaling pathways triggered by insulin or other factors. These compounds may facilitate the phosphorylation of key proteins involved in Glut4 translocation, promote the assembly of protein complexes at the plasma membrane, or affect the affinity of Glut4 for its transporter vesicles. By influencing the activation of Glut4, these compounds play a crucial role in glucose uptake and utilization within cells, contributing to metabolic homeostasis and energy production.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
As an activator of AMP-activated protein kinase (AMPK), AICAR can stimulate the translocation of Glut4 to the cell membrane independently of insulin, enhancing glucose uptake. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
As thiazolidinediones (TZDs) and PPARγ agonists, these compounds increase the expression and translocation of Glut4 to the cell surface, promoting glucose uptake in adipose tissue and muscle. | ||||||
Pioglitazone hydrochloride | 112529-15-4 | sc-204848 sc-204848A | 100 mg 500 mg | $62.00 $209.00 | 19 | |
As thiazolidinediones (TZDs) and PPARγ agonists, these compounds increase the expression and translocation of Glut4 to the cell surface, promoting glucose uptake in adipose tissue and muscle. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
A plant alkaloid, berberine is known to activate AMPK. This activation can promote the translocation of Glut4, enhancing cellular glucose uptake independently of insulin. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Found in grapes and red wine, resveratrol enhances AMPK activity. This action promotes the translocation of Glut4 to the cell surface, boosting glucose uptake. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Primarily known as an inhibitor of phosphoinositide 3-kinase (PI3K), wortmannin affects the PI3K pathway. Though typically used in research to inhibit insulin-stimulated Glut4 translocation, its effects are context-dependent. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $108.00 $200.00 $426.00 | 9 | |
A thiazolidinedione drug, troglitazone elevates Glut4 expression and activity, enhancing glucose uptake into cells. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
An isoflavone found in soy products, genistein stimulates the translocation of Glut4 to the cell surface, potentially through the activation of AMPK, leading to increased glucose uptake. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
By activating adenylate cyclase, forskolin elevates intracellular cAMP levels. This can influence various cellular pathways, some of which might promote Glut4 translocation, though the exact mechanisms are complex. | ||||||
Oleanolic Acid | 508-02-1 | sc-205775 sc-205775A | 100 mg 500 mg | $84.00 $296.00 | 8 | |
A triterpenoid compound, oleanolic acid has been demonstrated to stimulate the translocation of Glut4 to the cell surface, enhancing glucose uptake in muscle cells. | ||||||