GLUD2 Inhibitors

The term GLUD2 Inhibitors in this context refers to a class of chemicals that can indirectly influence the activity of GLUD2 (Glutamate Dehydrogenase 2). Direct chemical inhibitors specifically targeting GLUD2 are not well-established, so the focus is on compounds that affect related metabolic pathways, enzyme activities, and neurotransmitter systems. These inhibitors work through various mechanisms to potentially impact GLUD2 activity. Compounds like Riluzole, Memantine, and Lamotrigine modulate glutamatergic neurotransmission, potentially altering glutamate levels in the brain, which could indirectly affect GLUD2 activity due to changes in substrate availability. EGCG, found in green tea, is known for its broad effects on metabolic enzymes and could potentially influence GLUD2. Similarly, Gabapentin and Topiramate, which affect glutamate synthesis and neurotransmission, might indirectly impact GLUD2 activity.

Ammonium Chloride alters ammonia levels, which could affect the reaction equilibrium of GLUD2, potentially influencing its activity. L-Methionine Sulfoximine, an inhibitor of glutamine synthetase, might increase glutamate levels, indirectly affecting GLUD2. Compounds like α-Ketoglutarate, a product of the GLUD2 reaction, might exert feedback control over the enzyme. Benzodiazepines and Valproic Acid, which modulate GABAergic signaling, could indirectly impact glutamate metabolism, and thereby GLUD2 activity. Glutamine, as a key metabolite in glutamate metabolism, could also influence GLUD2 activity through its role in interconnected metabolic pathways.