GLI-4 Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Cyclopamine directly antagonizes Smoothened (SMO), a key transmembrane protein in the Hedgehog (Hh) signaling pathway. By inhibiting SMO, cyclopamine can downregulate the downstream transcriptional activators of the GLI family, including GLI4, thus decreasing its expression levels in cells. | ||||||
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $80.00 $96.00 | 1 | |
Vismodegib is a selective inhibitor of the Hedgehog pathway effector Smoothened, which is essential for the activation of GLI transcription factors. By blocking Smoothened, vismodegib prevents the transcriptional activation and subsequent overexpression of GLI4 in the nucleus. | ||||||
GANT61 | 500579-04-4 | sc-202630 sc-202630A sc-202630B | 1 mg 5 mg 10 mg | $63.00 $128.00 $200.00 | 6 | |
GANT61 disrupts GLI-mediated transcription by directly binding to GLI proteins and inhibiting their DNA-binding capability. This interaction hinders GLI4 from attaching to DNA and initiating the transcription of its target genes, thereby decreasing its functional expression in the cell. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin elevates intracellular cAMP levels, which activates protein kinase A (PKA). Activated PKA can phosphorylate GLI proteins, thereby inhibiting their transcriptional activity. As a result, forskolin may lead to the decreased expression of GLI4 by reducing its transcriptional activation. | ||||||
Jervine | 469-59-0 | sc-200934 sc-200934A | 1 mg 5 mg | $66.00 $240.00 | 1 | |
Jervine operates similarly to cyclopamine in inhibiting the Hedgehog signaling pathway. By blocking Smoothened, jervine hampers the pathway's activation, which can lead to the decreased expression of GLI4 by preventing its transcriptional upregulation. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $76.00 $139.00 | 23 | |
Itraconazole, commonly known as an antifungal agent, also shows inhibitory activity against the Hedgehog signaling pathway. This inhibition can decrease the expression of GLI4 by curtailing the transcriptional activity that would typically be induced by pathway activation. | ||||||
Erismodegib | 956697-53-3 | sc-396280 sc-396280A | 10 mg 100 mg | $255.00 $918.00 | ||
Erismodegib binds to and inhibits Smoothened, leading to a downregulation of the Hedgehog signaling pathway and subsequent decrease in GLI4 expression. This compound's action specifically diminishes the ability of GLI4 to promote the transcription of Hedgehog target genes. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $87.00 $224.00 | ||
Arsenic trioxide can cause the degradation of GLI proteins, potentially including GLI4, by promoting their removal from the cell nucleus and facilitating their breakdown. The result is a significant decrease in GLI4 protein levels and a corresponding reduction in its gene regulatory functions. | ||||||
SANT-1 | 304909-07-7 | sc-203253 | 5 mg | $132.00 | 5 | |
SANT-1 is a potent antagonist of Smoothened. By inhibiting Smoothened, SANT-1 can lead to the downregulation of Hedgehog pathway activity and consequent decrease in GLI4 expression, as the transcriptional activation of GLI4 is highly dependent on this pathway. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide has been shown to repress the transcription of a wide array of genes by inhibiting RNA polymerase II activity. This effect would lead to a significant reduction in GLI4 mRNA synthesis, thereby decreasing GLI4 protein expression and its transcriptional influence on downstream genes. | ||||||