GLEPP1 Activators
GLEPP1 activators constitute a specialized group of compounds that engage with the protein Glomerular Epithelial Protein 1 (GLEPP1), also known as protein-tyrosine phosphatase receptor type O (PTPRO). GLEPP1 is a receptor-type protein tyrosine phosphatase that is primarily expressed in kidney podocytes and is involved in the regulation of these cells' function and morphology. The activation of GLEPP1 typically involves the enhancement of its phosphatase activity, which is pivotal in modulating signaling pathways associated with cell shape and function.
Direct activators of GLEPP1 may bind to the protein and promote its catalytic activity, thereby increasing the dephosphorylation of specific tyrosine residues on downstream signaling molecules. This enhancement could be achieved by the stabilization of GLEPP1's active conformation or by inducing allosteric changes that increase its enzymatic efficiency. The activation of GLEPP1 can lead to alterations in the phosphorylation status of key proteins within the podocyte, affecting processes such as cytoskeletal dynamics, which are crucial for maintaining the structural integrity of the glomerular filtration barrier. Indirect activators of GLEPP1 might not engage with the protein directly but can still enhance its activity. These could include compounds that increase the expression levels of GLEPP1 through transcriptional upregulation or mRNA stabilization. They might also affect the cellular localization of GLEPP1, ensuring it is present in the right subcellular compartment for its action. Furthermore, indirect activators can modulate the activity of other proteins that interact with GLEPP1, such as kinases or other phosphatases, which could lead to a secondary increase in GLEPP1 activity due to changes in the cellular signaling context.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is an essential trace element that can bind to protein tyrosine phosphatases and enhance their enzymatic activity. By binding to GLEPP1, it directly enhances its phosphatase activity, leading to increased functional activity. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium orthovanadate is a potent inhibitor of protein tyrosine phosphatases. By inhibiting other phosphatases, it can indirectly enhance the functional activity of GLEPP1 by increasing the pool of phosphorylated proteins available for GLEPP1 to act on. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, it indirectly enhances the functional activity of GLEPP1 by increasing the pool of phosphorylated proteins available for GLEPP1 to act on. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $89.00 $279.00 | 6 | |
Cantharidin is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, it indirectly enhances the functional activity of GLEPP1 by increasing the pool of phosphorylated proteins available for GLEPP1 to act on. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, it indirectly enhances the functional activity of GLEPP1 by increasing the pool of phosphorylated proteins available for GLEPP1 to act on. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a potent activator of adenylyl cyclase, increasing levels of cAMP. Elevated levels of cAMP can stimulate protein kinase A (PKA) which can phosphorylate and enhance the functional activity of GLEPP1. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, leading to increased cAMP levels. Elevated cAMP levels can stimulate PKA which can phosphorylate and enhance the functional activity of GLEPP1. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine is a hormone and neurotransmitter that stimulates the adrenergic receptors, leading to increased cAMP levels. Elevated cAMP levels can stimulate PKA which can phosphorylate and enhance the functional activity of GLEPP1. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $326.00 $485.00 | 3 | |
Norepinephrine is a hormone and neurotransmitter that stimulates the adrenergic receptors, leading to increased cAMP levels. Elevated cAMP levels can stimulate PKA which can phosphorylate and enhance the functional activity of GLEPP1. | ||||||