girdin Activators
Girdin activators constitute a diverse group of chemicals pivotal in regulating Girdin, a crucial participant in cellular events such as migration, adhesion, and cytoskeletal dynamics. These activators employ various mechanisms to influence Girdin's activity, either directly or indirectly. For instance, Lithium chloride and BIO indirectly activate Girdin by impeding GSK-3β, thereby enhancing Girdin's stability and its involvement in Wnt signaling pathways. Forskolin directly triggers Girdin activation by elevating cAMP levels, leading to heightened Girdin phosphorylation and subsequently influencing cell migration. Y-27632 activates Girdin through ROCK inhibition, facilitating Girdin's participation in cytoskeletal rearrangements.
Calyculin A, known for its role as a protein phosphatase inhibitor, sustains Girdin phosphorylation, exerting a positive impact on pathways associated with cell migration and adhesion. On the other hand, SB-431542 activates Girdin by inhibiting the TGF-β pathway, releasing Girdin from negative regulation and amplifying its involvement in cellular processes. Collectively, these chemicals underscore the intricate network of signaling pathways converging on Girdin. This provides researchers with a comprehensive toolkit to precisely modulate Girdin's functions, offering valuable insights into the nuanced regulation of cellular behavior.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride activates Girdin indirectly by inhibiting GSK-3β, a kinase that negatively regulates Girdin expression. This leads to the stabilization of Girdin and its increased availability for interactions in signaling cascades, particularly in Wnt pathways. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates Girdin by stimulating adenylate cyclase, leading to increased cAMP levels. Elevated cAMP activates PKA, which in turn phosphorylates Girdin and enhances its binding to various partners, promoting its role in cell migration and cytoskeletal dynamics. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 activates Girdin through ROCK inhibition. This leads to the enhanced stability of Girdin and its localization to the leading edge of migrating cells, facilitating its involvement in cytoskeletal rearrangements and cell motility. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A, a protein phosphatase inhibitor, activates Girdin indirectly by preventing its dephosphorylation. This sustains Girdin in a phosphorylated state, promoting its association with other signaling molecules, especially in pathways involving cellular migration and adhesion. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB-431542 activates Girdin by inhibiting the TGF-β pathway. Girdin, negatively regulated by TGF-β, becomes more available for participation in signaling cascades involved in cell migration and proliferation. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $148.00 $597.00 | 75 | |
NSC23766 activates Girdin by inhibiting Rac1, a negative regulator of Girdin function. Reduced Rac1 activity allows Girdin to exert its effects on cytoskeletal dynamics and cell migration, enhancing its role in various signaling pathways. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
GSK-3 Inhibitor IX (BIO) activates Girdin by inhibiting GSK-3β, similar to lithium chloride. By preventing GSK-3β-mediated degradation of Girdin, BIO promotes its stability and availability for participation in Wnt signaling pathways, influencing cell migration and differentiation. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
A-769662 activates Girdin by stimulating AMPK, leading to increased Girdin phosphorylation. Phosphorylated Girdin plays a crucial role in modulating cellular processes related to energy homeostasis and cell migration. | ||||||
Wnt Agonist | 853220-52-7 | sc-222416 sc-222416A | 5 mg 25 mg | $154.00 $597.00 | 23 | |
Wnt Agonist (BML-284) activates Girdin by modulating the Wnt pathway. By influencing the canonical Wnt signaling, BML-284 enhances Girdin's role in cell migration and cytoskeletal organization, providing a regulatory link between Wnt signaling and Girdin function. | ||||||