GIMAP3 Activators
The class of compounds identified as GIMAP3 Activators encompasses a spectrum of molecules that influence T-cell activation and function. Phorbol 12-myristate 13-acetate (PMA) and ionomycin are two such compounds; PMA functions by activating PKC, a critical signaling kinase in T-cells, thereby promoting a cellular environment that necessitates the regulatory function of GIMAP3. Similarly, ionomycin elevates intracellular calcium, a second messenger quintessential for T-cell activation and signaling cascades, where GIMAP3 is likely to modulate immune responses. Forskolin and isoprenaline, through their elevation of cAMP levels, can create conditions favoring T-cell activation and proliferation, thereby potentially increasing the functional activity of GIMAP3 as it plays a part in regulating these processes.
Additionally, compounds like Cyclosporin A and Rapamycin, despite their primary immunosuppressive actions, can also indirectly influence the functional environment of GIMAP3. Cyclosporin A, by inhibiting calcineurin, leads to the activation of NFAT, a transcription factor essential for T-cell activation, thus potentially enhancing GIMAP3's role in a compensatory or regulatory capacity. Rapamycin, by inhibiting the mTOR pathway, affects T-cell metabolism and survival, indirectly fostering conditions that could necessitate GIMAP3's involvement in maintaining T-cell homeostasis and function. Prostaglandin E2 and Sphingosine-1-phosphate, through their receptor-mediated signaling, modulate T-cell responses and trafficking, respectively, both of which are processes where GIMAP3 could be implicated in modulatory roles.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in signal transduction for T-cell activation. Enhanced PKC activity leads to downstream signaling events that can augment T-cell survival and function, processes in which GIMAP3 is implicated. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin serves as a calcium ionophore, elevating intracellular calcium levels which are crucial for T-cell activation and signaling. Elevated calcium levels can enhance the survival and function of T-cells, indirectly supporting the role of GIMAP3. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can promote T-cell activation and proliferation. Increased T-cell activity necessitates regulatory proteins like GIMAP3 to maintain cellular homeostasis. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A inhibits calcineurin, leading to the activation of nuclear factor of activated T-cells (NFAT), which is critical for T-cell activation. This indirect mechanism can enhance the context in which GIMAP3 operates. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 interacts with its receptors on T-cells, modulating cyclic AMP levels and thus influencing T-cell immune responses. This modulation can enhance the survival and activity of T-cells, where GIMAP3 is involved. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore, which can mimic ionomycin's effect of elevating intracellular calcium, crucial for T-cell function and potentially enhancing GIMAP3's regulatory role. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts protein transport by inhibiting the exchange of protein ADP-ribosylation factor, which can influence T-cell activation and thus indirectly affect GIMAP3 function. | ||||||
Concanavalin A | 11028-71-0 | sc-203007 sc-203007A sc-203007B | 50 mg 250 mg 1 g | $117.00 $357.00 $928.00 | 17 | |
Concanavalin A is a lectin that can potently stimulate T-cells and induce cellular proliferation, thereby potentially enhancing the role of GIMAP3 in T-cell regulation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P engages with its receptors to regulate lymphocyte egress from lymphoid organs, which is a critical step in T-cell mediated immune responses, potentially augmenting GIMAP3's role in T-cell function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is a central regulator of T-cell metabolism and survival, thereby influencing the functional activity of GIMAP3 within T-cells by promoting a regulatory environment. | ||||||