Date published: 2025-10-8

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Gem Inhibitors

The chemical class referred to as GEM Inhibitors encompasses a diverse array of compounds that can inhibit the activity of the GEM protein, a member of the GTPase family, by targeting either the protein directly or its associated signaling pathways. This class consists of small molecule inhibitors which are known to interact with various elements of cellular signaling cascades. The compounds within this class are recognized for their ability to modulate the activity of small GTPases or the pathways they influence, although they are not selective for GEM. Instead, these inhibitors can affect GEM activity by altering the balance of intracellular signaling networks, which in turn can regulate GEM's role in these pathways. The approach to inhibiting GEM involves utilizing compounds that can disrupt the normal function of proteins within the same family as GEM or the signaling pathways that GEM is known to associate with.

The inhibitors can bind to their targets with high affinity, leading to changes in cellular processes that GEM is believed to affect, such as cytoskeletal dynamics, cell cycle progression, and vesicle trafficking. The interaction with these processes is based on the established roles of the compounds within this class in modulating GTPase signaling. By influencing the regulatory mechanisms of related GTPases and their pathways, these inhibitors can indirectly affect the regulatory actions of GEM. This indirect mode of action is a common thread that ties together the various members of the GEM Inhibitors class, providing a means to alter the function of GEM through a network-centric approach to inhibition. The design and selection of these compounds are rooted in the understanding of the molecular mechanisms governing GTPase signaling and their interconnectivity with multiple cellular processes.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

NSC 23766

733767-34-5sc-204823
sc-204823A
10 mg
50 mg
$148.00
$597.00
75
(4)

NSC 23766 disrupts the interaction between Rac1 and its specific guanine nucleotide exchange factors (GEFs), Trio and Tiam1, preventing the activation of Rac1. Since GEM is a GTPase that can influence similar pathways, NSC 23766 could indirectly affect GEM's signaling through cross-talk or shared regulatory mechanisms.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3K), which are upstream regulators of many signaling pathways, including those involving small GTPases like GEM. Inhibition of PI3K can alter the signaling environment and potentially reduce GEM activity.

PP 2

172889-27-9sc-202769
sc-202769A
1 mg
5 mg
$92.00
$223.00
30
(1)

PP2 is a selective inhibitor of Src family tyrosine kinases, which are involved in multiple signaling pathways, including those regulating cytoskeletal dynamics. Src kinase inhibition could therefore potentially impact GEM's activity indirectly.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$39.00
$90.00
212
(2)

PD98059 selectively inhibits MEK1/2, which are upstream of ERK in the MAPK pathway. Since MAPK pathways can influence GTPase activity, inhibition by PD98059 could have downstream effects on GEM's function.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

SB203580 is a selective inhibitor of p38 MAPK, affecting cellular responses to stress and cytokines. By modulating this pathway, the inhibitor could indirectly influence the signaling context in which GEM operates.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

Wortmannin is a potent inhibitor of PI3K, similar to LY294002, and would thus affect the same upstream signaling pathways potentially connected to GEM's regulatory role.

Brefeldin A

20350-15-6sc-200861C
sc-200861
sc-200861A
sc-200861B
1 mg
5 mg
25 mg
100 mg
$30.00
$52.00
$122.00
$367.00
25
(3)

Brefeldin A inhibits ADP-ribosylation factor (ARF), a GTPase involved in vesicle trafficking. By disrupting ARF function, this compound can alter membrane processes and indirectly affect related GTPases like GEM.