GDNF Inhibitors
Common GDNF Inhibitors include, but are not limited to K-252a CAS 99533-80-9, Erbstatin Analog CAS 63177-57-1, Purmorphamine CAS 483367-10-8, Isofagomine D-Tartrate CAS 957230-65-8 and Bisindolylmaleimide I (GF 109203X) CAS 133052-90-1.
GDNF inhibitors belong to a class of compounds designed to modulate the activity of Glial cell-derived neurotrophic factor (GDNF). GDNF is a protein that plays a crucial role in promoting the survival and maintenance of various types of neurons in the nervous system. It exerts its effects by binding to specific receptors on the surface of target cells, initiating intracellular signaling pathways that contribute to neuronal growth, survival, and differentiation.
By targeting the activity of GDNF, these inhibitors aim to regulate the signaling cascades initiated by GDNF binding to its receptors. This modulation of GDNF activity can have wide-ranging effects on neuronal development, function, and maintenance. The study of GDNF inhibitors contributes to our understanding of the intricate mechanisms involved in neural growth and survival, and their implications for neurological health. These inhibitors provide researchers with valuable tools to explore the role of GDNF in various cellular processes and its significance in neural development and function. Through the manipulation of GDNF signaling, these inhibitors offer insights into the complex interactions between growth factors and neuronal pathways, contributing to advancements in our understanding of neurobiology.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
K-252a | 99533-80-9 | sc-200517 sc-200517B sc-200517A | 100 µg 500 µg 1 mg | $129.00 $214.00 $498.00 | 19 | |
Inhibits the tyrosine kinase activity of the RET receptor, which is a receptor for GDNF, blocking GDNF signaling. | ||||||
Erbstatin Analog | 63177-57-1 | sc-200511 sc-200511A | 5 mg 25 mg | $83.00 $305.00 | 4 | |
Inhibits GDNF-induced neurite outgrowth in neurons, potentially affecting GDNF-mediated cellular responses. | ||||||
Purmorphamine | 483367-10-8 | sc-202785 sc-202785A | 1 mg 5 mg | $57.00 $184.00 | 18 | |
An activator of the Sonic hedgehog signaling pathway that can enhance GDNF-induced neuroprotection. | ||||||
Isofagomine D-Tartrate | 957230-65-8 | sc-207767 sc-207767A sc-207767C sc-207767B | 5 mg 10 mg 50 mg 25 mg | $387.00 $724.00 $2015.00 $1223.00 | ||
A fusion protein that neutralizes GDNF activity by binding to GDNF and preventing its interaction with receptors. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
A kinase inhibitor that can impact GDNF signaling pathways, potentially affecting cellular responses to GDNF. | ||||||
5-Iodotubercidin | 24386-93-4 | sc-3531 sc-3531A | 1 mg 5 mg | $153.00 $464.00 | 20 | |
Inhibits GDNF-induced signaling and subsequent cell survival through modulation of RET receptor activity. | ||||||
Ro 08-2750 | 37854-59-4 | sc-203682 sc-203682A | 1 mg 10 mg | $188.00 $416.00 | 1 | |
An inhibitor of the RET kinase domain that may interfere with GDNF-induced signaling and cellular responses. | ||||||
Janex-1 | 202475-60-3 | sc-205354 sc-205354A | 1 mg 5 mg | $36.00 $153.00 | 1 | |
Inhibits RET kinase activity, potentially impacting GDNF-induced RET phosphorylation and downstream signaling. | ||||||