Ro 08-2750 is an inhibitor of NGF-induced apoptosis. At submicromolar concentrations, Ro 08-2750 inhibits binding selectively to p75NTR. At higher concentrations, Ro 08-2750 inhibits binding selectively to P75NTR and TrkA. In SK-N-MC cells, it prevents NGF-induced apoptosis. Ro 08-2750 is an inhibitor of NGFR.
1. Niederhauser, O., et al. 2000. J. Neurosci. Res. 61: 263-272. 2. Arkin, M.R. and Wells, J.A. 2004. Nat. Rev Drug Discov. 3: 301-317.
Soluble in 1eq. NaOH (50 mM), and DMSO (10 mM).
Store at -20° C
~1.6 g/cm3 (Predicted)
n20D 1.75 (Predicted)
NGF: IC50 = 1 µM (human)
pKa: 9.75 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn