Ro 08-2750 CAS: 37854-59-4
MF: C13H10N4O3
MW: 270.24
A TrkA inhibitor and NGF-induced apoptosis inhibitor.

Ro 08-2750 (CAS 37854-59-4)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 114ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Alternate Names: 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde
Application: Ro 08-2750 is a TrkA inhibitor and NGF-induced apoptosis inhibitor
CAS Number: 37854-59-4
Molecular Weight: 270.24
Molecular Formula: C13H10N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Ro 08-2750 is an inhibitor of NGF-induced apoptosis. At submicromolar concentrations, Ro 08-2750 inhibits binding selectively to p75NTR. At higher concentrations, Ro 08-2750 inhibits binding selectively to P75NTR and TrkA. In SK-N-MC cells, it prevents NGF-induced apoptosis. Ro 08-2750 is an inhibitor of NGFR.


References

1. Niederhauser, O., et al. 2000. J. Neurosci. Res. 61: 263-272.
2. Arkin, M.R. and Wells, J.A. 2004. Nat. Rev Drug Discov. 3: 301-317.

Physical State :
Solid
Solubility :
Soluble in 1eq. NaOH (50 mM), and DMSO (10 mM).
Storage :
Store at -20° C
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.75 (Predicted)
IC50 :
NGF: IC50 = 1 µM (human)
pK Values :
pKa: 9.75 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD09038552
SMILES :
CC1=CC2=C(C=C1C=O)N(C3=NC(=O)NC(=O)C3=N2)C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Ro 08-2750 (CAS 37854-59-4)  Product Citations

See how others have used Ro 08-2750 (CAS 37854-59-4). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 30092219  Tong, B. et al. 2018. Exp. Cell Res. 371: 122-129.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 103ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 8ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2021 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.