Date published: 2026-4-5

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GCS Inhibitors

Santa Cruz Biotechnology now offers a broad range of GCS Inhibitors for use in various applications. GCS Inhibitors target glutamylcysteine synthetase (GCS), which is the rate-limiting enzyme in the biosynthesis of glutathione, a critical antioxidant that plays a key role in cellular defense mechanisms against oxidative stress. By inhibiting GCS, researchers can investigate the pathways and mechanisms through which glutathione synthesis is regulated and how its levels affect various cellular processes, including detoxification, apoptosis, and signal transduction. In scientific research, GCS Inhibitors are used to explore the effects of reduced glutathione levels on cellular responses to environmental stressors, providing insights into the role of glutathione in maintaining cellular redox balance and homeostasis. Researchers utilize GCS Inhibitors in high-throughput screening assays to discover new modulators of GCS activity, aiding in the identification of novel regulatory pathways and potential targets for further investigation. The use of GCS Inhibitors supports the development of experimental models to study the complex interactions between glutathione and other cellular components. Through these investigations, GCS Inhibitors contribute significantly to advancing knowledge in fields related to cellular stress responses, metabolism, and regulatory networks. View detailed information on our available GCS Inhibitors by clicking on the product name.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

ODQ

41443-28-1sc-200325
sc-200325A
10 mg
50 mg
$78.00
$222.00
13
(1)

ODQ is a selective guanylate cyclase stimulator that uniquely interacts with heme-containing enzymes, enhancing their catalytic activity. Its structure facilitates specific coordination with the heme group, promoting conformational changes that optimize enzyme function. The compound exhibits distinct reaction kinetics, characterized by rapid binding and prolonged effects on cyclic GMP levels. Additionally, its lipophilic nature influences membrane permeability, affecting cellular uptake and distribution.

Zinc Protoporphyrin-9

15442-64-5sc-200329
sc-200329A
25 mg
100 mg
$78.00
$213.00
31
(1)

Zinc Protoporphyrin-9 acts as a guanylate cyclase stimulator through its unique ability to bind to heme sites, influencing the electronic environment of adjacent catalytic residues. This interaction alters the redox potential, enhancing the enzyme's activity. Its stability in various pH conditions allows for consistent performance in biochemical pathways. The compound's distinct spectroscopic properties enable real-time monitoring of enzyme dynamics, providing insights into reaction mechanisms.

Methylene blue trihydrate

7220-79-3sc-203744
sc-203744A
5 g
25 g
$32.00
$62.00
3
(1)

Methylene blue trihydrate exhibits unique redox properties, facilitating electron transfer processes in various chemical environments. Its ability to form stable complexes with metal ions enhances its role in catalysis, influencing reaction kinetics. The compound's distinct chromophoric structure allows for effective light absorption, making it useful in photochemical applications. Additionally, its solubility in polar solvents contributes to its versatility in diverse chemical reactions, promoting efficient molecular interactions.

LY 83583

91300-60-6sc-200314
sc-200314A
5 mg
25 mg
$82.00
$230.00
3
(1)

LY 83583 is characterized by its reactivity as an acid halide, engaging in nucleophilic acyl substitution reactions that are pivotal in organic synthesis. Its electrophilic carbonyl group enhances its ability to form acyl derivatives with amines and alcohols, leading to diverse product formation. The compound's unique steric and electronic properties influence reaction rates and selectivity, making it a valuable intermediate in various synthetic pathways. Its stability under specific conditions further facilitates controlled reactions.

BAY 41-2272

256376-24-6sc-202491
sc-202491A
5 mg
25 mg
$238.00
$728.00
4
(0)

BAY 41-2272 exhibits notable reactivity as a GCS, primarily through its ability to form stable complexes with nucleophiles. The compound's unique electronic configuration allows for selective interactions with various functional groups, promoting efficient acylation processes. Its distinct steric hindrance influences the kinetics of reactions, enabling precise control over product formation. Additionally, BAY 41-2272's solubility characteristics enhance its compatibility in diverse reaction environments, facilitating innovative synthetic strategies.

AMP-Deoxynojirimycin

216758-20-2sc-223780
sc-223780A
500 µg
1 mg
$111.00
$208.00
(0)

AMP-Deoxynojirimycin functions as a GCS by engaging in specific hydrogen bonding interactions that stabilize enzyme-substrate complexes. Its unique stereochemistry allows for selective inhibition of glycosidases, altering reaction pathways and enhancing substrate specificity. The compound's dynamic solubility profile enables it to navigate various polar and non-polar environments, influencing reaction rates and product distribution. This versatility in molecular interactions contributes to its distinct reactivity in biochemical systems.