Date published: 2026-5-24

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GCS Antibodies

Santa Cruz Biotechnology features a diverse variety of GCS Antibodies for advanced research in the field of glycobiology. GCS Antibodies are compatible with multiple research applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). GCS, or glucosylceramidase, plays a critical role in the metabolism of glycosphingolipids, which are essential for cellular signaling and membrane integrity. Dysregulation of GCS has been implicated in several diseases, including Gaucher's disease and certain cancers, making it a significant target for therapeutic intervention. Understanding the function and regulation of GCS is crucial for developing strategies to combat these conditions. Research into GCS mechanisms has revealed important insights about cellular metabolism and disease progression. Ongoing studies continue to uncover new aspects of GCS function in both normal and pathological states. GCS research has opened promising avenues for therapeutic development in multiple disease areas. Santa Cruz Biotechnology monoclonal antibodies for GCS support researchers worldwide in advancing our understanding of cellular processes and disease mechanisms.

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GCS Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

GCS-α-1 Antibody (D-9)

sc-376502mouse IgG1 κ1-155 (h)WB, IP, IF, ELISAm, r, h
3
(4)

GCS-β-1 Antibody (G-3)

sc-514183mouse IgG1 κ541-619 (h)WB, IP, IF, ELISAm, r, h
4
(4)

GCS CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

GCS-α-1 Double Nickase Plasmid (h)

sc-405263-NIChGene KnockoutPuromycin0
(0)

GCS-α-1 Double Nickase Plasmid (h2)

sc-405263-NIC-2hGene KnockoutPuromycin0
(0)

GCS-β-1 CRISPR/Cas9 KO Plasmid (h)

sc-403225hGene KnockoutGFP0
(0)

GCS-β-1 HDR Plasmid (h)

sc-403225-HDRhHomology Directed RepairPuromycin0
(0)

GCS-β-1 Double Nickase Plasmid (h)

sc-403225-NIChGene KnockoutPuromycin0
(0)

GCS-β-1 Double Nickase Plasmid (h2)

sc-403225-NIC-2hGene KnockoutPuromycin0
(0)

GCS-α-2 Double Nickase Plasmid (h)

sc-404305-NIChGene KnockoutPuromycin0
(0)

GCS-α-2 Double Nickase Plasmid (h2)

sc-404305-NIC-2hGene KnockoutPuromycin0
(0)

GCS CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

GCS-β-1 CRISPR Activation Plasmid (h)

sc-403225-ACThGene ActivationPuro, Blast, Hygro0
(0)

GCS-β-1 CRISPR Activation Plasmid (h2)

sc-403225-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

GCS-α-2 CRISPR Activation Plasmid (h)

sc-404305-ACThGene ActivationPuro, Blast, Hygro0
(0)

GCS siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

GCS-α-1 siRNA (h)

sc-41010hGene SilencingN/A0
(0)

GCS-α-1 shRNA Plasmid (h)

sc-41010-SHhGene SilencingPuromycin0
(0)

GCS-α-1 shRNA (h) Lentiviral Particles

sc-41010-VhGene SilencingPuromycin0
(0)

GCS-α-1 siRNA (m)

sc-41011mGene SilencingN/A0
(0)

GCS-α-1 shRNA Plasmid (m)

sc-41011-SHmGene SilencingPuromycin0
(0)

GCS-α-1 shRNA (m) Lentiviral Particles

sc-41011-VmGene SilencingPuromycin0
(0)

GCS-α-1 siRNA (r)

sc-60101rGene SilencingN/A0
(0)

GCS-α-1 shRNA Plasmid (r)

sc-60101-SHrGene SilencingPuromycin0
(0)

GCS-α-1 shRNA (r) Lentiviral Particles

sc-60101-VrGene SilencingPuromycin0
(0)

GCS-β-1 siRNA (h)

sc-36486hGene SilencingN/A
1
(0)

GCS-β-1 shRNA Plasmid (h)

sc-36486-SHhGene SilencingPuromycin
1
(0)

GCS-β-1 shRNA (h) Lentiviral Particles

sc-36486-VhGene SilencingPuromycin
1
(0)

GCS-β-1 siRNA (m)

sc-36487mGene SilencingN/A0
(0)

GCS-β-1 shRNA Plasmid (m)

sc-36487-SHmGene SilencingPuromycin0
(0)

GCS-β-1 shRNA (m) Lentiviral Particles

sc-36487-VmGene SilencingPuromycin0
(0)

GCS-β-1 siRNA (r)

sc-60102rGene SilencingN/A
3
(0)

GCS-β-1 shRNA Plasmid (r)

sc-60102-SHrGene SilencingPuromycin
3
(0)

GCS-β-1 shRNA (r) Lentiviral Particles

sc-60102-VrGene SilencingPuromycin
3
(0)

GCS-α-2 siRNA (h)

sc-41012hGene SilencingN/A0
(0)

GCS-α-2 shRNA Plasmid (h)

sc-41012-SHhGene SilencingPuromycin0
(0)

GCS-α-2 shRNA (h) Lentiviral Particles

sc-41012-VhGene SilencingPuromycin0
(0)

GCS-α-2 siRNA (m)

sc-41013mGene SilencingN/A0
(0)

GCS-α-2 shRNA Plasmid (m)

sc-41013-SHmGene SilencingPuromycin0
(0)

GCS-α-2 shRNA (m) Lentiviral Particles

sc-41013-VmGene SilencingPuromycin0
(0)

GCS-β-2 siRNA (h)

sc-41014hGene SilencingN/A0
(0)

GCS-β-2 shRNA Plasmid (h)

sc-41014-SHhGene SilencingPuromycin0
(0)

GCS-β-2 shRNA (h) Lentiviral Particles

sc-41014-VhGene SilencingPuromycin0
(0)

GCS-β-2 siRNA (m)

sc-41015mGene SilencingN/A0
(0)

GCS-β-2 shRNA Plasmid (m)

sc-41015-SHmGene SilencingPuromycin0
(0)

GCS-β-2 shRNA (m) Lentiviral Particles

sc-41015-VmGene SilencingPuromycin0
(0)