Molecular structure of ODQ, CAS Number: 41443-28-1
ODQ (CAS 41443-28-1)
See product citations (13)
Alternate Names:
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
Application:
ODQ is a selective and potent sGC (soluble guanylyl cyclase) inhibitor
CAS Number:
41443-28-1
Purity:
≥98%
Molecular Weight:
187.15
Molecular Formula:
C9H5N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ODQ is a selective and potent GCS (soluble guanylyl cyclase, sGC) inhibitor that binds competitively with nitric oxide. The GCS (sGC) serves as a receptor for nitric oxide, which is involved in the production of cyclic guanosine monophosphate (cGMP). In prostate cancer cell studies, ODQ induced caspase-3, enhanced cell death, and blocked cell migration. Inhibition of GCS (sGC) through ODQ results in blocking the actions of nitric oxide on vascular and platelet smooth muscle.
ODQ (CAS 41443-28-1) References
- Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG. | Chan, SL. and Fiscus, RR. 2003. Mol Hum Reprod. 9: 775-83. PMID: 14614039
- cGMP-independent anti-tumour actions of the inhibitor of soluble guanylyl cyclase, ODQ, in prostate cancer cell lines. | Haramis, G., et al. 2008. Br J Pharmacol. 155: 804-13. PMID: 18695639
- Can guanine-based purines be considered modulators of intestinal motility in rodents? | Zizzo, MG., et al. 2011. Eur J Pharmacol. 650: 350-5. PMID: 20940015
- Action of lipopolysaccharide on interstitial cells of cajal from mouse small intestine. | Zuo, DC., et al. 2012. Pharmacology. 90: 151-9. PMID: 22890360
- The role of the NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of duloxetine in the forced swimming test. | Zomkowski, AD., et al. 2012. Pharmacol Biochem Behav. 103: 408-17. PMID: 23010381
- Zerumbone Alleviates Neuropathic Pain through the Involvement of l-Arginine-Nitric Oxide-cGMP-K⁺ ATP Channel Pathways in Chronic Constriction Injury in Mice Model. | Zulazmi, NA., et al. 2017. Molecules. 22: PMID: 28358309
- Cannabinoids Regulate the Diameter of Pericyte-Containing Retinal Capillaries in Rats. | Zong, Y., et al. 2017. Cell Physiol Biochem. 43: 2088-2101. PMID: 29059679
- Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. | Garthwaite, J., et al. 1995. Mol Pharmacol. 48: 184-8. PMID: 7544433
- Novel guanylyl cyclase inhibitor potently inhibits cyclic GMP accumulation in endothelial cells and relaxation of bovine pulmonary artery. | Brunner, F., et al. 1996. J Pharmacol Exp Ther. 277: 48-53. PMID: 8613957
- cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase. | Moro, MA., et al. 1996. Proc Natl Acad Sci U S A. 93: 1480-5. PMID: 8643658
- Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. | Schrammel, A., et al. 1996. Mol Pharmacol. 50: 1-5. PMID: 8700100
- Inhibition of nitrergic relaxations by a selective inhibitor of the soluble guanylate cyclase. | Cellek, S., et al. 1996. Br J Pharmacol. 118: 137-40. PMID: 8733586
- Interactions between endothelium-derived relaxing factors in the rat hepatic artery: focus on regulation of EDHF. | Zygmunt, PM., et al. 1998. Br J Pharmacol. 124: 992-1000. PMID: 9692786
Inhibitor of:
C20orf152, C22orf13, CNBD2, GCS, GCS-α-1, GCS-β-2, Guanylate Cyclase (GUCA), Olfr1178, Olfr612, Olfr889, OR1D5, ROS-GC1, sGC α1, sGC α2, sGC α2I, sGC β1, sGC β2, V1rg10, Vmn1r139, and Vmn2r38.Activator of:
NPY2-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ODQ, 10 mg | sc-200325 | 10 mg | $78.00 | |||
ODQ, 50 mg | sc-200325A | 50 mg | $222.00 |