ODQ CAS: 41443-28-1
MF: C9H5N3O2
MW: 187.15
A selective and potent sGC (soluble guanylyl cyclase) inhibitor.

ODQ (CAS 41443-28-1)

ODQ | CAS 41443-28-1 is rated 5.0 out of 5 by 1.
  • y_2020, m_4, d_3, h_20
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200325, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 134ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
Application: A selective and potent sGC (soluble guanylyl cyclase) inhibitor
CAS Number: 41443-28-1
Purity: ≥98%
Molecular Weight: 187.15
Molecular Formula: C9H5N3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

ODQ is a selective and potent GCS (soluble guanylyl cyclase, sGC) inhibitor that binds competitively with nitric oxide. The GCS (sGC) serves as a receptor for nitric oxide, which is involved in the production of cyclic guanosine monophosphate (cGMP). In prostate cancer cell studies, ODQ induced caspase-3, enhanced cell death, and blocked cell migration. Inhibition of GCS (sGC) through ODQ results in blocking the actions of nitric oxide on vascular and platelet smooth muscle.


References

1. Garthwaite, J., et al. 1995. Mol. Pharmacol. 48: 184-188. PMID: 7544433
2. Cellek, S., et al. 1996. Br. J. Pharmacol. 118: 137-140. PMID: 8733586
3. Brunner, F., et al. 1996. J. Pharmacol. Exp. Ther. 277: 48-53. PMID: 8613957
4. Schrammel, A., et al. 1996. Mol. Pharmacol. 50: 1-5. PMID: 8700100
5. Moro, M.A., et al. 1996. Proc. Natl. Acad. Sci. U.S.A. 93: 1480-1485. PMID: 8643658
6. Chan, S.L. and Fiscus, R.R. 2003. Mol. Hum. Reprod. 9: 775-783. PMID: 14614039
7. Haramis, G., et al. 2008. Br. J. Pharmacol. 155: 804-813. PMID: 18695639

Physical State :
Solid
Solubility :
Soluble in ethanol (1.2 mg/ml), DMSO (5 mg/ml), chloroform (10 mg/ml), acetonitrile (20 mg/ml), ethyl acetate, DMF (~30 mg/ml), and 1:1 solution of DMF:PBS(pH7.2) (~100 µg/ml). Insoluble in water.
Storage :
Store at -20° C
Melting Point :
160-170° C
Boiling Point :
~321.3° C at 760 mmHg (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.78 (Predicted)
IC50 :
Guanylate cyclase: IC50 = 20 nM
pK Values :
pKb: 0.94 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
1456
MDL Number :
MFCD00792620
SMILES :
C1=CC=C2C(=C1)N=CC3=NOC(=O)N23

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

ODQ  Product Citations

See how others have used ODQ. Click on the entry to view the PubMed entry .

Citations 1 to 8 of 8 total

PMID: # 30585261  Yoo, YM. et al. 2018. Int. J. Biol. Sci. 14: 1974-1984.

PMID: # 27158388  Xu, Z. et al. 2016. Am J Transl Res. 8: 1027-36.

PMID: # 26907804  2016. Neuropharmacology. 105: 508-19.

PMID: # 27261193  Wu, B. et al. 2016. Free Radic. Biol. Med. 97: 179-191.

PMID: # 27606143  Çakmak, E. et al. 2016. Balkan Med J. 33: 453-7.

PMID: # 25963768  Nethi, SK. et al. 2015. Nanoscale. 7: 9760-70.

PMID: # 23948706  Ulrich, C. et al. 2013. American journal of physiology. Cell physiology. 305: C803-16.

PMID: # 18406400  Wang, J. et al. 2008. Brain Res. 1209: 1-7.

Citations 1 to 8 of 8 total

Estaríamos interesados en el presupuesto de un bulk de ODQ nº CAS: 41443-28-1 Nos gustaría saber para 0.5, 1, 2 o 5gr

Asked by: Marta33
Please contact our Special Orders Department to inquire about availability and to receive a quote for a bulk quantity of this chemical. Please call our Technical Service Department, or email <[email protected]>.
Answered by: Tech Service
Date published: 2019-10-21
  • y_2020, m_4, d_3, h_20CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_200325, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 199ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Squecco Squecco, R. et al. (PubMed 26360621) investigated the ability of the hormone relaxin to induce changes in the resting membrane potential and on sarcolemmal ion channels of colonic smooth muscle cells that are related to its mechanical activity. They observed that relaxin caused a decay of the basal tone coupled to an increase of the spontaneous contractions, completely abolished by the guanylate cyclase inhibitor ODQ (1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one) -SCBT Publication Review
Date published: 2015-04-19
  • y_2020, m_4, d_3, h_20
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200325, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 23ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.