Molecular structure of LY 83583, CAS Number: 91300-60-6
LY 83583 (CAS 91300-60-6)
See product citations (3)
Alternate Names:
6-Anilinoquinoline-5,8-quinone
Application:
LY 83583 is an inhibitor of guanylate cyclase
CAS Number:
91300-60-6
Purity:
≥95%
Molecular Weight:
250.25
Molecular Formula:
C15H10N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
LY 83583 is a quinolinedione that inhibits soluble guanylate cyclase (GCS). Inhibition of GCS has been reported to lower levels of cGMP and cAMP in rat studies. LY 83583 may act to inhibit leukotriene synthesis in guinea-pig lung and rat peritoneal cells in vitro, block the release of endothelium-derived relaxing factor, and enhance glucose transporter-1-mediated glucose transport. Kinetic studies have reported that LY 83583 acts as a competitive inhibitor with respect to NADPH (Ki=2.257 muM). LY 83583 is an inhibitor of glutathione reductase.
LY 83583 (CAS 91300-60-6) References
- Endothelial modulation of vasoconstrictor responses in the perfused rabbit ovarian vascular bed. | Yousif, MH., et al. 1999. Pharmacology. 59: 106-14. PMID: 10450065
- LY 83583 interferes with the release of endothelium-derived relaxing factor and inhibits soluble guanylate cyclase. | Mülsch, A., et al. 1988. J Pharmacol Exp Ther. 247: 283-8. PMID: 2902213
- Pharmacologic analysis of two novel inhibitors of leukotriene (slow reacting substance) release. | Fleisch, JH., et al. 1984. J Pharmacol Exp Ther. 229: 681-9. PMID: 6202867
- Nitric oxide synthase activity in guinea pig ventricular myocytes is not involved in muscarinic inhibition of cAMP-regulated ion channels. | Zakharov, SI., et al. 1996. Circ Res. 78: 925-35. PMID: 8620613
- Sodium nitroprusside stimulates Ca2+ -activated K+ channels in porcine tracheal smooth muscle cells. | Yamakage, M., et al. 1996. Am J Physiol. 270: L338-45. PMID: 8638725
- Rebound stimulation of the cAMP-regulated Cl- current by acetylcholine in guinea-pig ventricular myocytes. | Zakharov, SI. and Harvey, RD. 1997. J Physiol. 499 (Pt 1): 105-20. PMID: 9061643
- Nitric oxide stimulates glucose transport and metabolism in rat skeletal muscle in vitro. | Young, ME., et al. 1997. Biochem J. 322 (Pt 1): 223-8. PMID: 9078265
- Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. | Ziche, M., et al. 1997. J Clin Invest. 99: 2625-34. PMID: 9169492
- Induction of nitric oxide synthase in rat gastric smooth muscle preparations. | Zheng, XL., et al. 1997. Am J Physiol. 273: G1101-7. PMID: 9374708
- Transient corneal edema induced by nitric oxide synthase inhibition. | Yanagiya, N., et al. 1997. Nitric Oxide. 1: 397-403. PMID: 9441910
- Guanylyl cyclase inhibition reduces contractility and decreases cGMP and cAMP in isolated rat hearts. | Klabunde, RE., et al. 1998. Cardiovasc Res. 37: 676-83. PMID: 9659451
- Sodium nitroprusside-induced cGMP-independent vasodilator responses in the perfused rabbit ovarian vascular bed. | Yousif, MH., et al. 1998. Pharmacol Res. 38: 381-6. PMID: 9806818
- Inhibition of nitric oxide formation and superoxide generation during reduction of LY83583 by neuronal nitric oxide synthase. | Kumagai, Y., et al. 1998. Eur J Pharmacol. 360: 213-8. PMID: 9851588
Inhibitor of:
GCS, and Glutathione reductase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LY 83583, 5 mg | sc-200314 | 5 mg | $82.00 | |||
LY 83583, 25 mg | sc-200314A | 25 mg | $230.00 |