GCP6 Activators
GCP6, a crucial component of the gamma-tubulin ring complex, plays a significant role in microtubule nucleation and spindle assembly, key processes in cell division. The functional activity of GCP6 can be influenced by various chemical compounds that modulate microtubule dynamics. Compounds such as Paclitaxel, Epothilone B, and Taxol, which stabilize microtubules, can indirectly enhance GCP6's activity by preventing microtubule depolymerization. This stabilization leads to an increased demand for GCP6's role in microtubule nucleation, essential for maintaining cellular structure and function during cell division.
Conversely, compounds like Nocodazole, Vinblastine, Vincristine, and Podophyllotoxin, which disrupt microtubule assembly or promote their depolymerization, create a cellular environment where GCP6's role becomes more critical. The disruption of microtubule networks by these agents necessitates a compensatory mechanism for microtubule reassembly, where GCP6's activity in microtubule nucleation is vital. Additionally, the inhibition of spindle dynamics by Kinesin-5 inhibitors (e.g., Monastrol) and the influence of cell shape and division by agents like Cytochalasin D and Griseofulvin indirectly augment the necessity for GCP6 in organizing and stabilizing microtubules. Methotrexate, by affecting cell division processes, can also influence the demand for GCP6's activity. These compounds, through their varied effects on microtubule dynamics and cell division, highlight the essential role of GCP6 in cellular organization, underscoring its importance in the maintenance of cellular integrity and the proper execution of cell division.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their depolymerization, which could indirectly enhance GCP6 activity in microtubule nucleation and stabilization. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
A microtubule depolymerizing agent, Nocodazole can enhance the demand for GCP6 activity in microtubule reassembly and organization. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine disrupts microtubule assembly, which could lead to increased GCP6 activity to compensate for disrupted microtubule dynamics. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin and inhibits microtubule polymerization, potentially enhancing GCP6's role in microtubule nucleation. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Similar to Paclitaxel, Epothilone B stabilizes microtubules, potentially increasing the requirement for GCP6 in maintaining microtubule integrity. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Inhibiting Kinesin-5 can disrupt spindle dynamics, potentially increasing the role of GCP6 in spindle assembly and microtubule organization. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
A microtubule destabilizing agent, Podophyllotoxin can enhance GCP6 activity in response to disrupted microtubule networks. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
While primarily affecting actin filaments, Cytochalasin D can alter cell shape and division, potentially influencing GCP6 activity in microtubule organization. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function, which could lead to enhanced GCP6 activity in microtubule nucleation and stabilization. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate, an antimetabolite, can indirectly influence microtubule dynamics and cell division, potentially affecting GCP6 activity. | ||||||