GCL Inhibitors
GCL inhibitors target and modulate the activity of the enzyme known as glutamate-cysteine ligase (GCL), which is a pivotal player in the intricate cellular process of glutathione biosynthesis. Glutathione, a critical endogenous antioxidant, plays a crucial role in maintaining cellular redox balance and protecting cells from oxidative stress. GCL inhibitors function by disrupting the enzymatic function of GCL, impeding the formation of glutathione through the inhibition of the rate-limiting step involving the binding of glutamate and cysteine.
This intricate modulation of GCL's enzymatic activity leads to downstream effects on the cellular levels of glutathione, which, in turn, can impact various cellular functions and signaling pathways. The precise mechanism of action of GCL inhibitors involves intricate interactions at the molecular level, altering the active site of the enzyme and interfering with the binding of its substrates. The class of GCL inhibitors encompasses diverse chemical structures, each with its own specific mode of interaction with the GCL enzyme.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Buthionine sulfoximine | 83730-53-4 | sc-200824 sc-200824A sc-200824B sc-200824C | 500 mg 1 g 5 g 10 g | $286.00 $442.00 $1532.00 $2975.00 | 26 | |
BSO is a classic GCL inhibitor that irreversibly binds to the active site of GCL, preventing the formation of glutathione by blocking the first step of its synthesis. | ||||||
6-Diazo-5-oxo-L-norleucine | 157-03-9 | sc-227078 sc-227078A sc-227078B sc-227078C | 5 mg 25 mg 100 mg 250 mg | $88.00 $291.00 $926.00 $2195.00 | ||
DON inhibits GCL by mimicking the substrate L-glutamate, leading to the formation of a non-functional enzyme-substrate complex, thereby preventing glutathione synthesis. | ||||||
Diethylmaleate | 141-05-9 | sc-202577 | 5 g | $27.00 | 4 | |
DEM is an electrophilic compound that reacts with thiol groups on the GCL enzyme, causing enzyme inactivation and thus decreasing the production of glutathione. | ||||||
β-Mercaptoethanol | 60-24-2 | sc-202966A sc-202966 | 100 ml 250 ml | $90.00 $120.00 | 10 | |
2-Mercaptoethanol reduces disulfide bonds in proteins and can indirectly impact GCL by modulating the redox state of the cellular environment, influencing glutathione production. | ||||||
Acetaminophen | 103-90-2 | sc-203425 sc-203425A sc-203425B | 5 g 100 g 500 g | $41.00 $61.00 $194.00 | 11 | |
Paracetamol has been shown to inhibit GCL by affecting the expression of the enzyme, leading to reduced glutathione synthesis and potential cellular oxidative stress. | ||||||
L-Methionine [R,S]-Sulfoximine | 15985-39-4 | sc-207806 | 1 g | $396.00 | ||
Methionine Sulfoximine inhibits GCL by mimicking L-methionine and binding to the active site of the enzyme, blocking the synthesis of glutathione. | ||||||