GCL Activators
GCL (Glutamate-Cysteine Ligase) activators modulate the activity of the enzyme glutamate-cysteine ligase (GCL). This enzyme plays a pivotal role in the cellular antioxidant defense system by catalyzing the rate-limiting step in the synthesis of glutathione, a crucial intracellular thiol molecule. Glutathione is renowned for its significance in maintaining redox homeostasis within cells, detoxifying harmful reactive oxygen species (ROS), and safeguarding against oxidative stress-induced damage. GCL activators amplify the production of glutathione by facilitating the activity of GCL, hence fortifying the cell's defenses against oxidative stress.
Chemically, GCL activators can encompass a diverse array of small molecules or compounds, each with its unique structural features and mechanisms of action. These activators typically exert their influence on GCL through various pathways, including direct binding to the enzyme or modulation of its transcription and translation. The net effect of GCL activation is an upsurge in the cellular levels of glutathione, which, in turn, enhances the cell's ability to counteract oxidative insults.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
NAC is a precursor to cysteine, enhancing its availability as a substrate for GCL and promoting glutathione synthesis. | ||||||
L-Cysteine | 52-90-4 | sc-286072 sc-286072A sc-286072B sc-286072C sc-286072D | 25 g 100 g 500 g 5 kg 10 kg | $51.00 $112.00 $449.00 $1151.00 $2178.00 | 1 | |
L-Cysteine is a direct precursor to glutathione, serving as a substrate for GCL and facilitating glutathione synthesis. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $82.00 $2091.00 | 8 | |
GSH can act as a feedback activator by providing reduced glutathione, signaling the need for more glutathione and enhancing GCL activity. | ||||||
Cysteamine | 60-23-1 | sc-217991 sc-217991A sc-217991B | 5 g 25 g 50 g | $89.00 $238.00 $442.00 | 1 | |
Cysteamine, structurally related to cysteine, supplies cysteine as a precursor, supporting GCL in generating glutathione. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $37.00 $57.00 $151.00 $577.00 $1103.00 | ||
Methionine indirectly influences GCL activity by participating in the transsulfuration pathway, contributing to cysteine availability. | ||||||
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
Homocysteine impacts GCL activity indirectly through the transsulfuration pathway, influencing cysteine availability. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
SAMe indirectly affects GCL activity by modulating cysteine availability through its involvement in the transsulfuration pathway and methionine metabolism. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-lipoic acid is an antioxidant that may maintain glutathione levels and indirectly support GCL activity by protecting against oxidative stress. | ||||||