GATA-3 Activators
GATA-3 activators represent a diverse class of molecules that play a pivotal role in regulating gene expression and cellular differentiation, particularly within the context of the immune system. GATA-3 itself is a crucial transcription factor that belongs to the GATA family, characterized by its ability to bind to specific DNA sequences and modulate the expression of various genes. This family of activators is primarily associated with the development and differentiation of T cells, a critical component of the adaptive immune system. The activation of GATA-3 is central to the differentiation of T helper 2 (Th2) cells, a subset of T cells that specialize in orchestrating immune responses against parasitic infections, allergic reactions, and tissue repair.
GATA-3 activators encompass a wide array of compounds, including natural ligands, synthetic small molecules, and signaling intermediates. Retinoic acid (RA), for instance, is a well-known natural activator of GATA-3 expression, with a key role in the development of T cells in the gut-associated lymphoid tissue. These activators function by binding to specific regulatory regions in the GATA-3 gene or through signaling pathways that ultimately lead to increased GATA-3 expression. As a result, they contribute to the fine-tuning of immune responses by promoting the differentiation of Th2 cells and influencing downstream immune cascades. GATA-3 activators represent a fascinating area of research in immunology, shedding light on the intricate mechanisms governing immune cell differentiation and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is a metabolite of vitamin A and acts as an activator for GATA-3 expression in T cell development within the gut-associated lymphoid tissue. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diester of phorbol and is known for its role as a tumor promoter via the activation of protein kinase C (PKC). Activation of PKC can lead to enhanced transcriptional activity of GATA-3 by promoting the phosphorylation of proteins that interact with GATA-3 or by initiating signaling cascades that result in the upregulation of GATA-3 activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a short-chain fatty acid that acts as a histone deacetylase inhibitor (HDACi). By inhibiting HDAC, it leads to a more relaxed chromatin structure and can enhance the transcriptional activity of several genes including GATA-3 by increasing access to transcriptional machinery. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels and activation of protein kinase A (PKA). PKA can phosphorylate transcription factors and other proteins that collaborate with GATA-3 to enhance its transcriptional activity. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
The active form of vitamin D, 1,25-dihydroxyvitamin D3, binds to the vitamin D receptor (VDR), which can heterodimerize with retinoic X receptor (RXR). The VDR-RXR complex can interact with GATA-3 regulatory regions to enhance GATA-3 expression and activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3 (GSK-3). Inhibition of GSK-3 can stabilize proteins and transcription factors that interact with or regulate GATA-3, leading to an enhancement of GATA-3 activity. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 interacts with its receptors (EP receptors) and can activate downstream signaling pathways such as the cyclic AMP (cAMP) pathway. Activation of this pathway can lead to the activation of PKA, which may enhance GATA-3 activity by phosphorylation of associated proteins or GATA-3 itself. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is the main catechin found in green tea and has been found to influence numerous signaling pathways. It may enhance GATA-3 activity by modulating signaling pathways that involve transcription factor activation, although the precise mechanisms by which it may do so are not fully understood. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenol found in grapes and berries. It can activate sirtuin 1 (SIRT1), which deacetylates proteins and could influence the activity of transcription factors and co-regulators associated with GATA-3, potentially enhancing GATA-3 activity. | ||||||
Zoledronic acid, anhydrous | 118072-93-8 | sc-364663 sc-364663A | 25 mg 100 mg | $92.00 $256.00 | 5 | |
Zoledronic acid is a bisphosphonate that inhibits farnesyl pyrophosphate synthase, potentially affecting the prenylation and function of small GTPases, which can modulate transcription factor activity, including GATA-3. | ||||||