gasdermin C Activators
Gasdermin C (GSDMC) belongs to the gasdermin family, proteins recognized for their role in cell death and inflammation. The hallmark feature of gasdermin proteins is their ability to form pores in cellular membranes, which is key to their function in pyroptosis, a form of programmed cell death associated with inflammatory responses.
GSDMC, like other gasdermins, contains a C-terminal domain that inhibits the activity of the N-terminal domain. Upon specific cellular signals, GSDMC can be cleaved by inflammatory caspases or other proteases, which separates the inhibitory C-terminal domain from the N-terminal domain. The liberated N-terminal domain can then oligomerize and insert into cellular membranes, forming pores that disrupt membrane integrity. This pore formation can lead to cell swelling, lysis, and the release of inflammatory cytokines, thereby contributing to the inflammatory process.The exact triggers and regulatory mechanisms for GSDMC activation are less well-characterized compared to other members of the gasdermin family, such as gasdermin D (GSDMD). However, it is speculated that GSDMC may play a role in epithelial cell biology due to its expression patterns, possibly participating in the maintenance of epithelial barrier integrity or in the response to epithelial damage.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin functions by increasing intracellular calcium levels, which could trigger the oligomerization and pore-forming activity of gasdermin C in cells. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which could phosphorylate downstream targets affecting the activity of gasdermin C, potentially promoting its pore-forming functions. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that can increase intracellular calcium, potentially influencing the activation and function of gasdermin C. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM chelates intracellular calcium. The resultant calcium fluxes could indirectly activate gasdermin C by modulating cellular signaling pathways. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $179.00 $612.00 $1203.00 $5202.00 $9364.00 | 26 | |
Oligomycin disrupts mitochondrial ATP production, which can lead to cellular stress responses that may indirectly activate gasdermin C. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 engages with its receptors to activate adenylate cyclase and raise cAMP levels, potentially influencing signal transduction pathways that activate gasdermin C. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin elevates cAMP by activating adenylate cyclase, which could indirectly activate gasdermin C through PKA-dependent signaling pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), potentially affecting gasdermin C by altering calcium signaling. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
db-cAMP is a cAMP analog that activates PKA. It could indirectly activate gasdermin C by phosphorylating substrates that modulate its activity. | ||||||