γN-crystallin Inhibitors
γN-Crystallin inhibitors represent a group of compounds that target the pathways or cellular processes linked to γN-crystallin, a protein found in the eye's lens. Among them, compounds such as Sorbitol can lead to osmotic stress in the lens, indirectly influencing the stability and function of crystallins. Antioxidants like Quercetin, and Curcumin counteract oxidative stress, a prominent factor that can destabilize crystallins.
Epigallocatechin gallate, Baicalein, and Luteolin have anti-aggregative properties which prevent protein aggregation, a phenomenon that can affect crystallin proteins. On the other hand, the glucocorticoid Dexamethasone can induce cataract formation, possibly by affecting crystallin stability. Taurine bolsters the lens's defense against oxidative damage, ensuring the structural integrity of proteins like crystallins. Lastly, Rutin and Resveratrol, by their antioxidative nature, offer protective effects against damage that can impact the stability of crystallin proteins.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-Sorbitol | 50-70-4 | sc-203278A sc-203278 | 100 g 1 kg | $29.00 $69.00 | ||
Induces osmotic stress in the lens, which can destabilize γN-crystallin structure and function. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
As an antioxidant, it counters oxidative stress, which can denature γN-crystallin and impair its function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
By counteracting oxidative stress, it can preserve the native structure of γN-crystallin, preventing aggregation or malfunction. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Reduces oxidative stress and prevents protein aggregation, safeguarding γN-crystallin structure and function. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Can induce cataract formation, possibly destabilizing γN-crystallin and altering its native function. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Anti-aggregative properties prevent protein aggregation, ensuring γN-crystallin remains in its functional form. | ||||||
Taurine | 107-35-7 | sc-202354 sc-202354A | 25 g 500 g | $48.00 $102.00 | 1 | |
Protects against oxidative stress, preserving the structure and function of γN-crystallin. | ||||||
Rutin trihydrate | 250249-75-3 | sc-204897 sc-204897A sc-204897B | 5 g 50 g 100 g | $57.00 $72.00 $126.00 | 7 | |
Its antioxidant properties help to mitigate oxidative damage that can lead to γN-crystallin denaturation. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
By inhibiting oxidative stress and glycation, it supports the preservation of γN-crystallin's native structure and function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Offers protective antioxidative effects, counteracting damage that could destabilize γN-crystallin. | ||||||