γ1-Adaptin Inhibitors
The chemical class of γ1-Adaptin inhibitors encompasses compounds that affect the protein indirectly by targeting cellular pathways or processes related to its function. γ1-Adaptin plays a role in clathrin-mediated endocytosis, and thus, inhibitors of this process can serve to alter the functional state of γ1-Adaptin. Compounds such as Dynasore and Chlorpromazine function by hindering the formation of clathrin-coated pits and vesicles, thus affecting the recruitment and function of adaptor proteins including γ1-Adaptin. Wortmannin and Genistein target upstream signaling molecules like PI3K and tyrosine kinases, respectively, altering intracellular signaling cascades that can modulate the activity of proteins involved in vesicular trafficking.
Other compounds, such as Ikarugamycin and Pitstop 2, disrupt the physical interactions necessary for the formation of clathrin-coated vesicles. Brefeldin A and CK-666 target the vesicle formation and actin cytoskeleton rearrangement processes, which are essential for the proper functioning of γ1-Adaptin in vesicular trafficking. Endosidin4, not yet assigned a CAS number, is included based on its action on the exocyst complex involved in vesicle trafficking, which is a process where γ1-Adaptin is also pivotal. Collectively, these inhibitors act on various components of the cellular machinery that are essential for the proper localization and function of γ1-Adaptin, thus serving as indirect means to inhibit its activity.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Inhibits PI3K, which is involved in intracellular trafficking, potentially altering γ1-Adaptin's regulatory environment. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Inhibits dynamin, a GTPase essential for clathrin-mediated endocytosis, thereby affecting γ1-Adaptin function indirectly. | ||||||
Pitstop 2 | 1419320-73-2 | sc-507418 | 10 mg | $360.00 | ||
Blocks the interaction between clathrin and adaptor proteins, potentially affecting the function of γ1-Adaptin. | ||||||
Dansylcadaverine | 10121-91-2 | sc-214851 sc-214851A sc-214851B | 100 mg 250 mg 1 g | $52.00 $89.00 $240.00 | 4 | |
Inhibits transglutaminase which can indirectly impact endocytosis and hence γ1-Adaptin's activity. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Blocks clathrin-mediated endocytosis, which could indirectly inhibit γ1-Adaptin by disrupting vesicle formation. | ||||||
Ikarugamycin | 36531-78-9 | sc-202179 | 500 µg | $189.00 | 4 | |
Disrupts clathrin-coated pit formation, potentially impacting γ1-Adaptin's role in vesicular trafficking. | ||||||
Tyrphostin AG 879 | 148741-30-4 | sc-3557 sc-3557A | 5 mg 25 mg | $83.00 $328.00 | 4 | |
Inhibits TrkA receptor kinase, indirectly affecting signaling pathways that γ1-Adaptin may be involved in. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Disrupts ARF-dependent adaptor protein recruitment, potentially altering γ1-Adaptin function in vesicle formation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Inhibits tyrosine kinases, potentially affecting signaling cascades that influence γ1-Adaptin activity. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
Inhibits the Arp2/3 complex, which is involved in actin polymerization and may indirectly affect γ1-Adaptin's role. | ||||||