GABA T-2 Activators
GABA T-2 activators, as detailed in this context, encompass a wide variety of chemical compounds, each with its distinct mechanism of action that can influence the activity of Gamma-Aminobutyric Acid Transaminase type 2. Understanding the intricate balance of neurotransmission in the central nervous system is vital to discern how these chemicals play their roles. For instance, activators such as NMDA and AMPA, when they engage their respective receptors, amplify neuronal excitatory activity. This surge in excitation can trigger the synthesis and utilization of GABA to restore neuronal equilibrium. As a counter-response, GABA T-2 can increase its activity to regulate the heightened GABA levels.
Moreover, certain compounds, like Muscimol and Bicuculline, exert their influence by directly interacting with GABA receptors. Muscimol, being a GABA_A receptor agonist, mimics the actions of GABA, while Bicuculline antagonizes the same receptor. Such direct interactions with the GABAergic system underscore how endogenous GABA dynamics, and consequently GABA T-2 activity, can be modulated. Furthermore, the broader neurotransmitter landscape, including the roles of Dopamine, Serotonin, and Acetylcholine, showcases the interdependence of different neurotransmission pathways. These neurotransmitters don't act in isolation; instead, their activity can indirectly necessitate the modulation of GABA levels to ensure the harmonious functioning of neural circuits. As a result, GABA T-2's role becomes pivotal in maintaining the GABA balance, influenced indirectly by these activators.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Methyl-D-Aspartic acid (NMDA) | 6384-92-5 | sc-200458 sc-200458A | 50 mg 250 mg | $109.00 $369.00 | 2 | |
NMDA receptors, when activated, increase neuronal activity which could necessitate higher GABA levels for inhibition. An increase in GABA synthesis and utilization can potentially push GABA T-2 to act more intensively to maintain balance. | ||||||
Kainic acid monohydrate | 58002-62-3 | sc-269283 | 10 mg | $275.00 | ||
Kainic Acid activates the kainate receptors, leading to increased neuronal firing. This activity might necessitate higher GABA synthesis and turnover, potentially influencing GABA T-2 activity indirectly. | ||||||
Gabaculine | 59556-17-1 | sc-200473 sc-200473A sc-200473B | 10 mg 50 mg 250 mg | $354.00 $884.00 $3069.00 | 5 | |
Gabaculine is a known inhibitor of GABA T. However, in specific environments where feedback mechanisms are present, reduced activity of GABA T-2 might cause the body to upregulate its production or other forms, potentially having an indirect activation effect on other GABA T-2 molecules. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $297.00 $577.00 | ||
As a precursor for GABA synthesis, increasing levels of L-Glutamic Acid can lead to an increase in GABA production. Elevated GABA levels might necessitate more action from GABA T-2 to maintain balance, potentially leading to its indirect activation. | ||||||
(+)-Bicuculline | 485-49-4 | sc-202498 sc-202498A | 50 mg 250 mg | $82.00 $281.00 | ||
Bicuculline is a GABA_A receptor antagonist. Blocking GABA's inhibitory effects might cause the body to regulate endogenous GABA levels, potentially influencing GABA T-2 activity indirectly. | ||||||
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
Elevated Homocysteine can indirectly influence GABAergic pathways. Changes in these pathways can potentially modulate the dynamics of GABA turnover and thus GABA T-2 activity. | ||||||
(Aminomethyl)phosphonic acid | 1066-51-9 | sc-239227 | 250 mg | $62.00 | ||
AMPA receptor activation leads to increased neuronal activity. As with other excitatory compounds, this might indirectly push for higher GABA synthesis and turnover, potentially modulating GABA T-2. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopaminergic and GABAergic pathways interact in complex ways. Increased dopamine activity can indirectly modulate GABA turnover, potentially influencing GABA T-2. | ||||||
Serotonin hydrochloride | 153-98-0 | sc-201146 sc-201146A | 100 mg 1 g | $118.00 $187.00 | 15 | |
Serotonergic pathways have interactions with GABAergic pathways. Changes in serotonin levels or activity might indirectly modulate GABA turnover and thus GABA T-2 activity. | ||||||