GABA Metabolism and Transport
Items 31 to 40 of 87 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Valerenic acid | 3569-10-6 | sc-204377 sc-204377A | 1 mg 10 mg | $71.00 $474.00 | 1 | |
Valerenic acid plays a significant role in GABA metabolism and transport by modulating the activity of GABA transaminase, an enzyme crucial for GABA degradation. Its unique structural features facilitate interactions with the enzyme, potentially altering reaction kinetics and enhancing GABA levels. Additionally, valerenic acid may influence the transport of GABA across neuronal membranes, impacting synaptic dynamics and the balance of excitatory and inhibitory signals in the nervous system. | ||||||
Chlormethiazole hydrochloride | 6001-74-7 | sc-203548 sc-203548A | 10 mg 50 mg | $110.00 $385.00 | ||
Chlormethiazole hydrochloride interacts with GABAergic systems by inhibiting GABA transaminase, thereby affecting GABA metabolism. Its distinct molecular structure allows for specific binding to the enzyme, potentially altering its catalytic efficiency. This compound may also influence GABA transporter proteins, modulating the uptake and release of GABA in synaptic clefts. Such interactions can lead to changes in neurotransmitter availability, impacting neuronal excitability and signaling pathways. | ||||||
Guvacine hydrochloride | 6027-91-4 | sc-263347 | 25 mg | $93.00 | 1 | |
Guvacine hydrochloride plays a role in GABA metabolism by modulating the activity of GABA transporters, which are crucial for maintaining synaptic GABA levels. Its unique molecular configuration facilitates selective interactions with these transport proteins, potentially influencing their conformational states and transport kinetics. This compound may also affect the recycling of GABA, thereby altering the dynamics of neurotransmitter homeostasis and synaptic transmission. | ||||||
Dihydroergotoxine mesylate | 8067-24-1 | sc-203921 | 100 mg | $109.00 | ||
Dihydroergotoxine mesylate influences GABA metabolism through its interaction with GABAergic pathways, potentially altering the affinity and activity of GABA receptors. Its structural characteristics allow for specific binding to transport proteins, which may enhance or inhibit GABA uptake. This compound's unique ability to modulate receptor dynamics can lead to variations in neurotransmitter release and signaling, impacting overall synaptic function and balance within neural circuits. | ||||||
TACA | 38090-53-8 | sc-203705 sc-203705A | 10 mg 50 mg | $92.00 $296.00 | ||
TACA is a notable compound in GABA metabolism, functioning as a potent modulator of GABA transport mechanisms. Its unique structural features enable it to interact selectively with GABA transporters, influencing their affinity and transport kinetics. By altering the uptake and release of GABA, TACA can significantly impact synaptic GABA levels, thereby affecting neuronal signaling pathways and overall neurotransmitter balance in the brain. | ||||||
Stiripentol | 49763-96-4 | sc-208402 | 100 mg | $388.00 | ||
Stiripentol is a unique compound that interacts with GABA metabolism through its ability to inhibit GABA transaminase, thereby enhancing GABA levels in the synaptic cleft. Its structural features facilitate selective binding to GABA receptors, influencing receptor activation and downstream signaling pathways. Additionally, Stiripentol alters the kinetics of GABA transport, promoting increased neurotransmitter availability and contributing to the modulation of synaptic transmission dynamics. | ||||||
(−)-Bicuculline methochloride | 53552-05-9 | sc-203528 sc-203528A sc-203528B | 10 mg 50 mg 500 mg | $138.00 $635.00 $5200.00 | ||
(-)-Bicuculline methochloride is a potent antagonist of GABA receptors, specifically targeting the GABA_A subtype. Its unique structure allows for competitive inhibition, disrupting the normal binding of GABA and altering synaptic transmission. This compound also influences the kinetics of GABA transporters, potentially affecting the reuptake and recycling of GABA in neuronal pathways. Its interactions can lead to significant changes in neuronal excitability and synaptic plasticity. | ||||||
gamma-Acetylenic GABA | 57659-38-8 | sc-295002 sc-295002A | 1 mg 5 mg | $200.00 $400.00 | ||
Gamma-Acetylenic GABA is a selective inhibitor of GABA transaminase, an enzyme crucial for GABA metabolism. Its unique acetylenic group enhances binding affinity, leading to altered reaction kinetics and prolonged GABA availability in synaptic clefts. This compound modulates the balance of inhibitory neurotransmission by affecting GABA turnover, thereby influencing neuronal signaling pathways and synaptic dynamics without directly interacting with GABA receptors. | ||||||
Gabaculine | 59556-17-1 | sc-200473 sc-200473A sc-200473B | 10 mg 50 mg 250 mg | $347.00 $867.00 $3009.00 | 5 | |
Gabaculine is a potent inhibitor of GABA transaminase, characterized by its distinctive structural features that facilitate strong interactions with the enzyme's active site. This compound disrupts the normal metabolic pathway of GABA, resulting in a significant accumulation of this neurotransmitter. Its unique binding dynamics alter the enzyme's kinetics, effectively modulating GABA levels and impacting the overall neurotransmitter balance within the central nervous system. | ||||||
Vigabatrin | 60643-86-9 | sc-204382 sc-204382A sc-204382B sc-204382C | 10 mg 50 mg 100 mg 1 g | $96.00 $393.00 $520.00 $867.00 | 2 | |
Vigabatrin acts as a selective inhibitor of GABA transaminase, showcasing a unique ability to form stable covalent bonds with the enzyme. This interaction leads to a pronounced alteration in GABA metabolism, enhancing the neurotransmitter's availability. The compound's structural conformation allows for effective steric hindrance, influencing the enzyme's catalytic efficiency and shifting the equilibrium of GABA synthesis and degradation, thereby impacting neurotransmitter homeostasis. | ||||||