Vigabatrin (CAS 60643-86-9)
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Vigabatrin is a research chemical of significant interest in neuroscience due to its action as an irreversible inhibitor of the enzyme gamma-aminobutyric acid transaminase (GABA-T). In research applications, it is used to study the modulation of GABAergic neurotransmission and the resultant effects on neural circuitry. Studies involving vigabatrin explore its impact on GABA levels, providing insights into the role of this neurotransmitter in various neural processes. Additionally, vigabatrin serves as a tool for understanding the metabolic pathways involved in the GABA cycle and the potential consequences of altering GABA metabolism. The chemical is also used in experimental models to investigate the neurochemical basis of certain behavioral and neurophysiological phenomena.
Vigabatrin (CAS 60643-86-9) References
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- Vigabatrin: a novel therapy for seizure disorders. | Gidal, BE., et al. 1999. Ann Pharmacother. 33: 1277-86. PMID: 10630829
- Vigabatrin for refractory partial epilepsy. | Hemming, K., et al. 2008. Cochrane Database Syst Rev. CD007302. PMID: 18646179
- Vigabatrin for infantile spasms. | Pesaturo, KA., et al. 2011. Pharmacotherapy. 31: 298-311. PMID: 21361740
- Vigabatrin therapy for refractory complex partial seizures: review of major European trials. | Ben-Menachem, E. and Sander, JW. 2011. Acta Neurol Scand Suppl. 16-28. PMID: 22061177
- Vigabatrin monotherapy for infantile spasms. | Gaily, E. 2012. Expert Rev Neurother. 12: 275-86. PMID: 22364326
- Vigabatrin-associated retinal damage: potential biochemical mechanisms. | Heim, MK. and Gidal, BE. 2012. Acta Neurol Scand. 126: 219-28. PMID: 22632110
- Vigabatrin-associated visual field loss. | Fecarotta, C. and Sergott, RC. 2012. Int Ophthalmol Clin. 52: 87-94, xii. PMID: 22668542
- Vigabatrin for refractory partial epilepsy. | Hemming, K., et al. 2013. Cochrane Database Syst Rev. CD007302. PMID: 23440814
- Vigabatrin versus carbamazepine monotherapy for epilepsy. | Xiao, Y., et al. 2015. Cochrane Database Syst Rev. 2015: CD008781. PMID: 26580100
- Stiripentol and vigabatrin current roles in the treatment of epilepsy. | Chiron, C. 2016. Expert Opin Pharmacother. 17: 1091-101. PMID: 26933940
- Vigabatrin: Lessons Learned From the United States Experience. | Foroozan, R. 2018. J Neuroophthalmol. 38: 442-450. PMID: 29280765
- Vigabatrin - new data on indications and safety in paediatric epilepsy. | Golec, W., et al. 2021. Neurol Neurochir Pol. 55: 429-439. PMID: 34541635
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Vigabatrin, 10 mg | sc-204382 | 10 mg | $125.00 | |||
Vigabatrin, 50 mg | sc-204382A | 50 mg | $485.00 | |||
Vigabatrin, 100 mg | sc-204382B | 100 mg | $650.00 | |||
Vigabatrin, 1 g | sc-204382C | 1 g | $1015.00 |