G6Pase-β Activators
G6Pase-β Activators represents a category of compounds that can influence the function or activity of the G6Pase-β (G6PC3) enzyme, either directly or indirectly. These compounds operate by affecting the broader biochemical systems in which G6PC3 plays a role, specifically glucose metabolism, gluconeogenesis and glycogenolysis.
Hormones like glucagon, adrenaline, and cortisol are known to trigger glycogenolysis and gluconeogenesis, and their presence can indirectly increase G6PC3 activity. Moreover, the presence of glucose, an end product of gluconeogenesis and glycogenolysis, can indirectly reflect increased G6PC3 activity. On the other hand, insulin and metformin inhibit these processes, and in their absence, G6PC3 activity can increase. Furthermore, compounds like forskolin and IBMX, which increase intracellular cAMP levels, can indirectly activate G6PC3 by triggering gluconeogenesis and glycogenolysis. Collectively, these compounds and conditions, by modulating the various processes in which G6PC3 plays a role, can be termed as G6Pase-β Activators.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $37.00 $194.00 $64.00 | 5 | |
As an end product of gluconeogenesis and glycogenolysis, increased glucose levels can indirectly reflect increased G6PC3 activity. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin inhibits gluconeogenesis and glycogenolysis. In the absence of insulin, G6PC3 activity can therefore increase. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
(-)-Epinephrine is a hormone that triggers glycogenolysis and gluconeogenesis, processes in which G6PC3 is involved. The presence of adrenaline can therefore indirectly increase G6PC3 activity. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $100.00 | 6 | |
Cortisol is a hormone that promotes gluconeogenesis, a process in which G6PC3 is involved. The presence of cortisol can therefore indirectly increase G6PC3 activity. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine can indirectly increase G6PC3 activity by promoting glycogenolysis and gluconeogenesis. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin inhibits hepatic gluconeogenesis, a process in which G6PC3 is involved. In the absence of metformin, G6PC3 activity can therefore increase. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP levels which can activate Protein Kinase A (PKA). PKA can phosphorylate and activate enzymes involved in gluconeogenesis and glycogenolysis, indirectly activating G6PC3. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX inhibits phosphodiesterase (PDE), leading to increased intracellular cAMP levels. This can indirectly activate G6PC3 by promoting gluconeogenesis and glycogenolysis. | ||||||