FUNDC1 Inhibitors

FUNDC1 inhibitors constitute a chemical class of compounds that and reversibly target FUNDC1 (FUN14 domain-containing protein 1), a mitochondrial protein involved in regulating mitophagy, a crucial process responsible for the selective removal of damaged or dysfunctional mitochondria. These inhibitors are specifically engineered to interact with FUNDC1, aiming to disrupt its activity and modulate mitophagy. The chemical structure of FUNDC1 inhibitors enables them to bind to specific regions or binding sites on the protein, potentially interfering with its ability to initiate mitophagy or interact with other components of the mitophagy machinery. Researchers employ FUNDC1 inhibitors in biochemical and cellular studies to unravel the intricacies of FUNDC1's role in mitochondrial quality control and its potential implications in cellular health and disease. The design and development of these inhibitors rely on a comprehensive understanding of FUNDC1's structural features and its involvement in mitophagy regulation, providing valuable tools for advancing research in the field of mitochondrial biology and quality control mechanisms.