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Doxycycline Hyclate (CAS 24390-14-5) - chemical structure image
Molecular structure of Doxycycline Hyclate, CAS Number: 24390-14-5
Doxycycline Hyclate (CAS 24390-14-5) - chemical structure image
Molecular structure of Doxycycline Hyclate, CAS Number: 24390-14-5
Molecular structure of Doxycycline Hyclate, CAS Number: 24390-14-5

Doxycycline Hyclate (CAS 24390-14-5)

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Alternate Names:
Doxycycline Hyclate is known as a broad-spectrum tetracycline antibiotic.
Application:
Doxycycline Hyclate is an antimicrobial tetracycline that acts as an inhibitor of MMP-1, MMP-8 and MMP-9.
CAS Number:
24390-14-5
Purity:
≥98%
Molecular Weight:
512.94
Molecular Formula:
C22H24N2O8•HCl•1/2H2O•1/2C2H6O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Description
Technical Information
Safety Information
SDS & Certificate of Analysis

Doxycycline Hyclate, also called doxycycline, is an antimicrobial tetracycline that acts as an inhibitor of a wide range of matrix metalloproteinases. It has been observed to significantly decrease the levels and activity of metalloproteinase-9 (MMP-9) in corneal erosion studies. Rheumatoid arthriitis studies indicate that Doxycycline Hyclate can block the degradation of type II collagen, and not type I collagen, as well as down regulate the expression levels and activity of MMP-8. Reports suggest that Doxycycline Hyclate blocks collagen activity and in smooth muscle studies increases smooth muscle cell adhesion, and changes the reorganization of fibrillar collagen matrices and cell migration. Additionally, Doxycycline Hyclate has been observed to alter the expression of apicoplast genes in Plasmodium falciparum, and inhibit tissue formation in rat tissue studies. Doxycycline Hyclate is also known as Doxycycline hydrochloride hemiethanolate hemihydrate, Atridox, α-6-Deoxy-5-hydroxytetracycline, and (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)- 3,5,10,12,12a-pentahydroxy- 6-methyl- 1,11-dioxo- 1,4,4a,5,5a,6,11,12a-octahydrotetracene- 2-carboxamide hydrochloride hemiethanolate hemihydrate.


Doxycycline Hyclate (CAS 24390-14-5) References

  1. Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and corticosteroids.  |  Dursun, D., et al. 2001. Am J Ophthalmol. 132: 8-13. PMID: 11438047
  2. Doxycycline and tissue repair in rats.  |  Lamparter, S., et al. 2002. J Lab Clin Med. 139: 295-302. PMID: 12032490
  3. Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential.  |  Suomalainen, K., et al. 1992. Antimicrob Agents Chemother. 36: 227-9. PMID: 1317148
  4. Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices.  |  Franco, C., et al. 2006. Am J Pathol. 168: 1697-709. PMID: 16651635
  5. Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum.  |  Dahl, EL., et al. 2006. Antimicrob Agents Chemother. 50: 3124-31. PMID: 16940111
  6. The use and safety of doxycycline hyclate and other second-generation tetracyclines.  |  Sloan, B. and Scheinfeld, N. 2008. Expert Opin Drug Saf. 7: 571-7. PMID: 18759709
  7. Biowaiver monographs for immediate release solid oral dosage forms: Doxycycline hyclate.  |  Jantratid, E., et al. 2010. J Pharm Sci. 99: 1639-53. PMID: 19798752
  8. Development of doxycycline hyclate suppositories and pharmacokinetic study in rabbits.  |  Christ, AP., et al. 2020. Eur J Pharm Sci. 142: 105141. PMID: 31706017
  9. Tailored Doxycycline Hyclate Loaded In Situ Gel for the Treatment of Periodontitis: Optimization, In Vitro Characterization, and Antimicrobial Studies.  |  Ranch, KM., et al. 2021. AAPS PharmSciTech. 22: 77. PMID: 33595740
  10. Doxycycline Hyclate Modulates Antioxidant Defenses, Matrix Metalloproteinases, and COX-2 Activity Accelerating Skin Wound Healing by Secondary Intention in Rats.  |  Altoé, LS., et al. 2021. Oxid Med Cell Longev. 2021: 4681041. PMID: 33959214
  11. Doxycycline hyclate-loaded in situ forming gels composed from bleached shellac, Ethocel, and Eudragit RS for periodontal pocket delivery.  |  Senarat, S., et al. 2021. Saudi Pharm J. 29: 252-263. PMID: 33981174
  12. Niosome-encapsulated Doxycycline Hyclate for Potentiation of Acne Therapy: Formulation and Characterization.  |  Kashani-Asadi-Jafari, F. and Hadjizadeh, A. 2022. Pharm Nanotechnol. 10: 56-68. PMID: 35209832
  13. An efficacy trial of doxycycline chemoprophylaxis against leptospirosis.  |  Takafuji, ET., et al. 1984. N Engl J Med. 310: 497-500. PMID: 6363930
  14. Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-alpha and doxycycline.  |  Hanemaaijer, R., et al. 1997. J Biol Chem. 272: 31504-9. PMID: 9395486
  15. Doxycycline Hyclate  |  Reema S. Patel and Mayur Parmar. 2023. Statpearls.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Doxycycline Hyclate, 100 mg

sc-204734B
100 mg
$26.00

Doxycycline Hyclate, 1 g

sc-204734
1 g
$49.00

Doxycycline Hyclate, 5 g

sc-204734A
5 g
$105.00

Doxycycline Hyclate, 25 g

sc-204734C
25 g
$190.00

For how long can the product be stored at -20C before losing its properties? And how long can the aliquots be kept at 4C after thawing them to use them?

Asked by: Inforequest
We recommend not thawing out more than 2 times.
Answered by: Technical Service
Date published: 2024-01-25

Can this product be used in inducible mammalian expression systems?

Asked by: Onur
Thank you for your question. This biochemical, Doxycycline Hyclate, sc-204734, is an antimicrobial tetracycline that acts as an inhibitor of MMP-1, MMP-8 and MMP-9. It has not been specifically tested for inducible mammalian expression systems, so we do not have that information.
Answered by: Tech Service
Date published: 2019-07-09

what is the expiration date sc-204734A, Н1916 ?

Asked by: Olesya
Thank you for your question. The expiry date of Doxycycline Hyclate (CAS 24390-14-5), lot sc-204734A is August 19th 2021. For further information please contact our technical service team directly.
Answered by: Technical Support Europe
Date published: 2019-04-05

I am working with dox in DMEM and wanted to know what the half-life of dox is at 37c under physiological conditions?

Asked by: Danielvargas
Thank you for your question. Unfortunately, we have not tested the half-life of the material at 37 C. However, we are able to provide the following information: After this product was stored at a temperature of 40 (+/-) 2° C with humidity at 75 (+/-) 5%, the product showed a purity of 97.6% or greater after 6 months. After the product was stored at a temperature 25 (+/-) 2°C with humidity at 60 (+/-) 5%, the product showed a purity of 89.29% or greater after 48 months. I have also included the link to the PubChem page which has half-life information: https://pubchem.ncbi.nlm.nih.gov/compound/54686183#section=Metabolism-Metabolites
Answered by: Technical Support
Date published: 2017-10-30

What is the appearance of the chemical?

Asked by: two2igm05
Thank you for your question. The compound, sc-204734, is provided as a yellow crystalline powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com. or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-19

What is the solubility of this product?

Asked by: hawkeye11
Thanks for your question. Doxycycline Hyclate, sc-204734, is soluble in MeOH (10 mg/0.5 mL).
Answered by: TechService7
Date published: 2016-12-20
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Rated 5 out of 5 by from ForloniForloni, G. et al. (PubMed 12149459) injected Syrian hamsters intracerebrally with scrapie (a transmissible spongiform encephalopathy) infected brain homogenate and 1mM doxycycline hyclate. The hamsters treated with the doxycycline hyclate showed a significant delay in appearance of symptoms and increased survival time. -SCBT Publication Review
Date published: 2015-06-05
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Doxycycline Hyclate is rated 5.0 out of 5 by 1.
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