Date published: 2025-10-30

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FRMPD3 Inhibitors

The inhibition of FRMPD3, a protein involved in cytoskeletal organization and cell adhesion, can be achieved through various chemical compounds that target specific signaling pathways and cellular processes. Compounds that interfere with protein kinases have a pronounced effect, as they can disrupt signaling cascades that regulate the actin cytoskeleton, to which FRMPD3 contributes. In particular, compounds that inhibit actin filament formation or myosin function could impair FRMPD3's role in maintaining cellular morphology. By obstructing the polymerization of actin or the activity of non-muscle myosin II, these inhibitors would likely lead to a reduction in FRMPD3's ability to support cytoskeletal integrity. Furthermore, other classes of compounds targeting upstream regulatory pathways also play a pivotal role in modulating FRMPD3 activity. For example, chemicals that inhibit the PI3K/AKT or MAPK/ERK pathways can indirectly suppress FRMPD3's involvement in cell adhesion and motility by altering the signaling milieu that FRMPD3 operates within. Additionally, specific inhibition of the Rho-kinase pathway, Rac1 signaling, or p21-activated kinases, all of which are integral to cytoskeletal dynamics and cell movement, could attenuate the functional expression of FRMPD3.

Items 1 to 10 of 11 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$150.00
$388.00
113
(4)

This kinase inhibitor targets a broad spectrum of protein kinases, leading to downstream inhibition of various signaling pathways. In the context of FRMPD3, staurosporine may disrupt interactions with kinases that modulate the cytoskeletal organization and cell adhesion, functions that FRMPD3 is implicated in.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

A phosphoinositide 3-kinase (PI3K) inhibitor that impairs the PI3K/AKT pathway. Since FRMPD3 has been linked to cell adhesion and PI3K signaling is crucial in cell survival and motility, inhibition of this pathway can indirectly affect FRMPD3's role in these processes.

Wiskostatin

253449-04-6sc-204399
sc-204399A
sc-204399B
sc-204399C
1 mg
5 mg
25 mg
50 mg
$48.00
$122.00
$432.00
$812.00
4
(1)

A potent inhibitor of the N-WASP, which is involved in actin polymerization. Since FRMPD3 is associated with the regulation of the actin cytoskeleton, the inhibition of N-WASP would likely disrupt the normal function of FRMPD3 in actin dynamics.

(S)-(−)-Blebbistatin

856925-71-8sc-204253
sc-204253A
sc-204253B
sc-204253C
1 mg
5 mg
10 mg
25 mg
$71.00
$260.00
$485.00
$949.00
(2)

An inhibitor of non-muscle myosin II ATPase activity. This compound prevents proper myosin II function, which could interfere with FRMPD3's role in maintaining cytoskeletal integrity and cellular morphology.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$39.00
$90.00
212
(2)

An MEK inhibitor that interrupts the MAPK/ERK pathway. By inhibiting this pathway, PD 98059 could indirectly impact FRMPD3's function related to cell adhesion and motility that are regulated through MAPK/ERK signaling.

Y-27632, free base

146986-50-7sc-3536
sc-3536A
5 mg
50 mg
$182.00
$693.00
88
(1)

A selective inhibitor of the Rho-associated, coiled-coil containing protein kinase (ROCK). This kinase is intimately involved in actin cytoskeleton organization. Inhibition of ROCK might indirectly suppress FRMPD3's influence on cytoskeletal dynamics and cell shape.

NSC 23766

733767-34-5sc-204823
sc-204823A
10 mg
50 mg
$148.00
$597.00
75
(4)

A Rac1 inhibitor that suppresses Rac1-dependent cell motility and cytoskeletal reorganization. Since FRMPD3 is involved in actin cytoskeleton organization, NSC 23766 could indirectly reduce FRMPD3's functional activity in these processes.

Latrunculin A, Latrunculia magnifica

76343-93-6sc-202691
sc-202691B
100 µg
500 µg
$260.00
$799.00
36
(2)

An actin polymerization inhibitor that sequesters actin monomers and thus prevents filament formation. As FRMPD3 is associated with actin dynamics, the inhibition of actin polymerization by Latrunculin A would likely diminish FRMPD3's role in cytoskeletal organization.

ML-7 hydrochloride

110448-33-4sc-200557
sc-200557A
10 mg
50 mg
$89.00
$262.00
13
(1)

An inhibitor of myosin light chain kinase (MLCK), which is important in controlling actin-myosin contractility. FRMPD3, being involved in cytoskeletal modulation, might be functionally inhibited due to the disruption of actin-myosin dynamics by ML-7 hydrochloride.

Gö 6983

133053-19-7sc-203432
sc-203432A
sc-203432B
1 mg
5 mg
10 mg
$103.00
$293.00
$465.00
15
(1)

A protein kinase C (PKC) inhibitor that influences a variety of cellular processes, including cytoskeletal organization. The inhibition of PKC activity by Gö 6983 could indirectly affect the functional role of FRMPD3 in these processes.