FREM2 Inhibitors
FREM2 inhibitors belong to a distinctive chemical class that has garnered significant attention in the realm of molecular research due to their potential impact on cellular processes. These inhibitors target the FREM2 protein, a member of the FRAS1-related extracellular matrix (FRE) family, which plays a crucial role in embryonic development and tissue morphogenesis. The FREM2 protein is integral to the formation and maintenance of various tissues, particularly in the developing central nervous system and renal system.
FREM2 inhibitors is designed to interact selectively with the active sites or binding domains of the FREM2 protein, thereby modulating its activity. By impeding the normal functioning of FREM2, these inhibitors have the capacity to influence intricate cellular signaling cascades and molecular pathways. This, in turn, may result in altered cell adhesion, migration, and differentiation processes during embryonic development or tissue repair. The structural diversity within the FREM2 inhibitor class allows for a range of chemical modifications that can be explored to enhance potency and specificity, providing researchers with a versatile toolkit for investigating the intricacies of FREM2-related molecular mechanisms. Continued exploration of FREM2 inhibitors holds promise for advancing our understanding of fundamental biological processes and may open avenues for the development of novel tools for research and discovery in the broader field of cell biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
Interferes with TGF-β signaling which is involved in extracellular matrix formation, potentially influencing FREM2's role. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $77.00 $270.00 | 55 | |
Inhibits matrix metalloproteinases that remodel the extracellular matrix, potentially affecting FREM2's environment. | ||||||
3-Aminopropionitrile | 151-18-8 | sc-266473 | 1 g | $104.00 | ||
Inhibits lysyl oxidase, an enzyme that cross-links collagen and elastin, possibly altering FREM2's extracellular context. | ||||||
Cilengitide | 188968-51-6 | sc-507335 | 5 mg | $215.00 | ||
Targets integrins that are involved in cell-matrix interactions, potentially altering FREM2's associated pathways. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $96.00 $292.00 | 27 | |
Inhibits Wnt production, which could affect pathways related to FREM2's function in epithelial integrity. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Inhibits heat shock protein 90 which can affect client protein folding and may indirectly impact FREM2's function. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Inhibits Src family kinases, potentially affecting signaling pathways relevant to FREM2's function. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Inhibits Rho-associated protein kinase, which may affect cell shape and motility, potentially influencing FREM2's role. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
Inhibits glycogen synthase kinase 3 beta, possibly affecting Wnt signaling and indirectly impacting FREM2's function. | ||||||