FREM2 Antibody (F-1): sc-376555
- FREM2 Antibody (F-1) is a mouse monoclonal IgG1 κ FREM2 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 2281-2580 mapping within an internal region of FREM2 of human origin
- FREM2 Antibody (F-1) is recommended for detection of FREM2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-FREM2 Antibody (F-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to biotin for WB, IHC(P) and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for FREM2 Antibody (F-1) for WB applications. This reagent is now offered in a bundle with FREM2 Antibody (F-1) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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FREM2 Antibody (F-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects FREM2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FREM2 (F-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, biotin, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FREM2 protein, also known as FRAS1 related extracellular matrix protein 2, is a 3,169 amino acid single-pass type I membrane protein primarily located on the extracellular side of the cell membrane. This localization allows FREM2 to play a significant role in the extracellular matrix, which is essential for maintaining the structural integrity of tissues, particularly in the skin and renal epithelia. FREM2 is involved in epidermal adhesion events, which are vital for proper skin function and wound healing. Mutations in the gene encoding FREM2, located on human chromosome 13, can lead to Fraser syndrome, a multisystem malformation characterized by various developmental abnormalities, including ear defects and congenital heart issues. Additionally, FREM2 exists in multiple alternatively spliced isoforms, which may contribute to diverse functional roles in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FREM2 Antibody (F-1) References:
- The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis. | Smyth, I., et al. 2004. Proc Natl Acad Sci U S A. 101: 13560-5. PMID: 15345741
- Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs. | Jadeja, S., et al. 2005. Nat Genet. 37: 520-5. PMID: 15838507
- Tissue morphogenesis and vascular stability require the Frem2 protein, product of the mouse myelencephalic blebs gene. | Timmer, JR., et al. 2005. Proc Natl Acad Sci U S A. 102: 11746-50. PMID: 16087869
- Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects. | Kiyozumi, D., et al. 2006. Proc Natl Acad Sci U S A. 103: 11981-6. PMID: 16880404
- Fraser syndrome due to homozygosity for a splice site mutation of FREM2. | Shafeghati, Y., et al. 2008. Am J Med Genet A. 146A: 529-31. PMID: 18203166
- Molecular study of 33 families with Fraser syndrome new data and mutation review. | van Haelst, MM., et al. 2008. Am J Med Genet A. 146A: 2252-7. PMID: 18671281
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FREM2 Antibody (F-1) | sc-376555 | 200 µg/ml | $316.00 | |||
FREM2 Antibody (F-1): m-IgGκ BP-HRP Bundle | sc-523005 | 200 µg Ab, 40 µg BP | $354.00 | |||
FREM2 Antibody (F-1) AC | sc-376555 AC | 500 µg/ml, 25% agarose | $416.00 | |||
FREM2 Antibody (F-1) HRP | sc-376555 HRP | 200 µg/ml | $316.00 | |||
FREM2 Antibody (F-1) FITC | sc-376555 FITC | 200 µg/ml | $330.00 | |||
FREM2 Antibody (F-1) PE | sc-376555 PE | 200 µg/ml | $343.00 | |||
FREM2 Antibody (F-1) Alexa Fluor® 488 | sc-376555 AF488 | 200 µg/ml | $357.00 | |||
FREM2 Antibody (F-1) Alexa Fluor® 546 | sc-376555 AF546 | 200 µg/ml | $357.00 | |||
FREM2 Antibody (F-1) Alexa Fluor® 594 | sc-376555 AF594 | 200 µg/ml | $357.00 | |||
FREM2 Antibody (F-1) Alexa Fluor® 647 | sc-376555 AF647 | 200 µg/ml | $357.00 | |||
FREM2 Antibody (F-1) Alexa Fluor® 680 | sc-376555 AF680 | 200 µg/ml | $357.00 | |||
FREM2 Antibody (F-1) Alexa Fluor® 790 | sc-376555 AF790 | 200 µg/ml | $357.00 | |||
FREM2 Antibody (F-1) B | sc-376555 B | 200 µg/ml | $320.00 |