Frataxin Inhibitors
Frataxin inhibitors represent a class of chemical compounds that have garnered significant attention in the realm of molecular biology and cellular research due to their unique ability to modulate the expression and function of the frataxin protein. Frataxin, a highly conserved mitochondrial protein, plays a crucial role in iron-sulfur cluster biogenesis and iron homeostasis within cells. The inhibition of frataxin by specific compounds within this class has opened up avenues for exploring the fundamental mechanisms underlying iron metabolism and its implications for various cellular processes.
Frataxin inhibitors are typically small organic molecules that exert their effects by binding to the frataxin protein, thus interfering with its proper function. This class of compounds has been utilized primarily as research tools to investigate the physiological consequences of altered frataxin levels within cells. By inhibiting frataxin, researchers have been able to elucidate the intricate pathways that govern iron metabolism, iron-sulfur cluster assembly, and mitochondrial function. This, in turn, has provided valuable insights into the molecular basis of certain diseases, particularly those related to mitochondrial dysfunction and iron overload disorders.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin forms DNA adducts, potentially leading to DNA damage and altered gene expression, which could affect frataxin levels indirectly. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
As an anthracycline antibiotic, doxorubicin intercalates into DNA and disrupts topoisomerase-II activity, possibly affecting frataxin gene transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This cytidine analog incorporates into RNA and DNA, causing hypomethylation of DNA, which might influence frataxin gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase inhibitor, trichostatin A can change chromatin structure and potentially downregulate frataxin gene expression. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Exposure to arsenic compounds like Sodium (meta)arsenite has been linked to changes in gene expression and could affect frataxin levels. | ||||||
Lead(II) Acetate | 301-04-2 | sc-507473 | 5 g | $85.00 | ||
Lead Acetate Trihydrate exposure can disrupt cellular processes and potentially alter gene expression, potentially influencing frataxin levels. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
Cadmium exposure has been associated with changes in gene expression, potentially affecting frataxin protein levels. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
As a histone deacetylase inhibitor, valproic acid can alter chromatin structure and potentially downregulate frataxin expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to modulate various cellular pathways and gene expression, potentially influencing frataxin levels. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
This ribonucleotide reductase inhibitor can affect DNA synthesis and potentially alter frataxin gene expression. | ||||||