FOXL2 Inhibitors
FOXL2 inhibitors constitute a distinctive class of chemical compounds designed to modulate the activity of the FOXL2 gene, a crucial transcription factor associated with ovarian development and maintenance in mammals. The FOXL2 gene encodes a forkhead box transcription factor that plays a pivotal role in ovarian follicle maturation and granulosa cell differentiation. These inhibitors are meticulously crafted to selectively impede the functioning of FOXL2, thereby influencing downstream gene expression and cellular processes within the ovarian tissues.
At the molecular level, FOXL2 inhibitors typically exert their effects by binding to specific regions of the FOXL2 protein, disrupting its ability to interact with DNA and regulate target genes. By doing so, these inhibitors can alter the intricate balance of gene expression networks involved in ovarian development, impacting folliculogenesis and granulosa cell fate determination. The design and development of FOXL2 inhibitors often involve sophisticated computational modeling and structure-activity relationship studies to optimize their binding affinity and selectivity. Researchers aim to precisely manipulate FOXL2 function, unraveling its intricate regulatory mechanisms and paving the way for a deeper understanding of ovarian biology
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Estradiol can modulate estrogen receptor signaling, which potentially influences FOXL2 activity. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $256.00 | 18 | |
Tamoxifen acts as an estrogen receptor modulator, which can alter FOXL2 transcriptional activity. | ||||||
ICI 182,780 | 129453-61-8 | sc-203435 sc-203435A | 1 mg 10 mg | $81.00 $183.00 | 34 | |
Fulvestrant, an estrogen receptor degrader, can downregulate pathways involving FOXL2. | ||||||
Letrozole | 112809-51-5 | sc-204791 sc-204791A | 25 mg 50 mg | $85.00 $144.00 | 5 | |
Letrozole inhibits aromatase, potentially reducing estrogen and affecting FOXL2-related pathways. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine can cause DNA demethylation, potentially impacting FOXL2 gene expression. | ||||||
Selumetinib | 606143-52-6 | sc-364613 sc-364613A sc-364613B sc-364613C sc-364613D | 5 mg 10 mg 100 mg 500 mg 1 g | $28.00 $80.00 $412.00 $1860.00 $2962.00 | 5 | |
Selumetinib inhibits MEK1/2, which may interact with signaling pathways involving FOXL2. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor which can impact pathways that modulate FOXL2 function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which can affect translation of proteins in the FOXL2 pathway. | ||||||
Bicalutamide | 90357-06-5 | sc-202976 sc-202976A | 100 mg 500 mg | $41.00 $143.00 | 27 | |
Bicalutamide, an androgen receptor antagonist, may indirectly affect FOXL2 expression levels. | ||||||